Paired associative stimulation improves hand function after nontraumatic spinal cord injury: a case series

Show simple item record Tolmacheva, Aleksandra Savolainen, Sarianna Kirveskari, Erika Brandstack, Nina Mäkelä, Jyrki P. Shulga, Anastasia 2019-12-04T22:28:55Z 2019-12-04T22:28:55Z 2019-08-13
dc.identifier.citation Tolmacheva , A , Savolainen , S , Kirveskari , E , Brandstack , N , Mäkelä , J P & Shulga , A 2019 , ' Paired associative stimulation improves hand function after nontraumatic spinal cord injury: a case series ' , Clinical neurophysiology practice , vol. 4 , pp. 178–183 .
dc.identifier.other PURE: 126266647
dc.identifier.other PURE UUID: 0ac7ce1b-f1dc-4ef3-8787-5f69c73ca35f
dc.identifier.other RIS: urn:B8373A3715D64DB001AABC562721FD0E
dc.identifier.other ORCID: /0000-0003-0262-3570/work/65664581
dc.identifier.other WOS: 000498645400028
dc.description.abstract Objectives Long-term paired associative stimulation (PAS) is a non-invasive combination of transcranial magnetic stimulation and peripheral nerve stimulation and leads to improved hand motor function in individuals with incomplete traumatic tetraplegia. Spinal cord injuries (SCIs) can also be induced by neurological diseases. We tested a similar long-term PAS approach in patients with nontraumatic neurological SCI. Methods In this case series five patients with nontraumatic tetraplegia received PAS to the weaker upper limb 3 to 5 times per week for 6 weeks. Patients were evaluated with manual muscle testing (MMT) before and immediately after therapy and at the 1- and 6-month follow ups. Patients were also evaluated for spasticity, hand mechanical and digital dynamometry, pinch, and Box and Blocks tests. Results All patients had improved MMT values at all post-PAS evaluations. The mean±standard error MMT increase was 1.44±0.37 points (p=0.043) immediately after PAS, 1.57±0.4 points (p=0.043) at the 1-month follow-up, and 1.71±0.47 points (p=0.043) at the 6-month follow up. The pinch, digital dynamometry values, and Box and Blocks test results also improved in all patients. Conclusions Long-term PAS may be a safe and effective treatment for improving hand function in patients with nontraumatic tetraplegia. Significance This is the first report demonstrating the therapeutic potential of PAS for neurological SCI. en
dc.format.extent 6
dc.language.iso eng
dc.relation.ispartof Clinical neurophysiology practice
dc.rights cc_by_nc_nd
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3112 Neurosciences
dc.subject TMS
dc.subject Rehabilitation
dc.subject Plasticity
dc.subject Spinal Cord
dc.subject Paired Associative Stimulation
dc.subject Spinal Cord Injury
dc.subject INDUCTION
dc.subject Spinal cord injury
dc.subject RECOVERY
dc.subject PRIORITIES
dc.subject MOTOR CORTEX
dc.subject BRAIN
dc.subject PLASTICITY
dc.title Paired associative stimulation improves hand function after nontraumatic spinal cord injury: a case series en
dc.type Article
dc.contributor.organization HUS Medical Imaging Center
dc.contributor.organization BioMag Laboratory
dc.contributor.organization University of Helsinki
dc.contributor.organization Department of Neurosciences
dc.contributor.organization Kliinisen neurofysiologian yksikkö
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization HUS Neurocenter
dc.contributor.organization Neurologian yksikkö
dc.description.reviewstatus Peer reviewed
dc.relation.issn 2467-981X
dc.rights.accesslevel openAccess
dc.type.version publishedVersion
dc.type.version draft

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