Pineoblastomas : A long-term follow up study of three cases in Helsinki Neurosurgery

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Choque-Velasquez , J , Resendiz-Nieves , J C , Jahromi , B R , Colasanti , R , Tynninen , O , Collan , J , Niemelä , M & Hernesniemi , J 2019 , ' Pineoblastomas : A long-term follow up study of three cases in Helsinki Neurosurgery ' , Interdisciplinary neurosurgery: advanced techniques and case management , vol. 18 , 100477 . https://doi.org/10.1016/j.inat.2019.100477

Title: Pineoblastomas : A long-term follow up study of three cases in Helsinki Neurosurgery
Author: Choque-Velasquez, Joham; Resendiz-Nieves, Julio C.; Jahromi, Behnam Rezai; Colasanti, Roberto; Tynninen, Olli; Collan, Juhani; Niemelä, Mika; Hernesniemi, Juha
Contributor: University of Helsinki, Clinicum
University of Helsinki, HUS Neurocenter
University of Helsinki, HUS Neurocenter
University of Helsinki, Medicum
University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, Department of Neurosciences
University of Helsinki, HUS Neurocenter
Date: 2019-12
Language: eng
Number of pages: 5
Belongs to series: Interdisciplinary neurosurgery: advanced techniques and case management
ISSN: 2214-7519
URI: http://hdl.handle.net/10138/307926
Abstract: Background Pineoblastomas are very rare malignant lesions with a bad prognosis and high mortality during the first five years from diagnosis. Report of cases We present a retrospective review of three patients with histologically confirmed pineoblastomas consecutively operated on between 1997 and 2015. One of our patients died >14 years after surgery, and the other 2 patients are still alive and in good condition without recurrence of the disease >12 years after surgery. All of them underwent gross total resection and craniospinal radiotherapy. Individualized scheme of chemotherapy was administered in two cases. The cornerstones for the surgical resection of pineoblastomas are reported. Conclusions A proper multidisciplinary management of pineoblastomas, which associates gross total microsurgical resection of the lesion and an adjuvant therapy determined by our neurooncology team based on accurate craniospinal adjuvant radiotherapy with boost of radiation on the tumoral bed, and when needed, an adequate but aggressive medulloblastoma-like chemotherapy, may improve the overall survival of these malignant lesions.
Subject: 3112 Neurosciences
3124 Neurology and psychiatry
3126 Surgery, anesthesiology, intensive care, radiology
Chemotherapy
Microneurosurgery
Pineal region lesions
Pineoblastomas
Radiotherapy
Sitting position
Supracerebellar infratentorial approach
HEALTH-ORGANIZATION CLASSIFICATION
SURVIVAL
PINEAL REGION TUMORS
CENTRAL-NERVOUS-SYSTEM
FEATURES
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