Pineoblastomas : A long-term follow up study of three cases in Helsinki Neurosurgery

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http://hdl.handle.net/10138/307926

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Choque-Velasquez , J , Resendiz-Nieves , J C , Jahromi , B R , Colasanti , R , Tynninen , O , Collan , J , Niemelä , M & Hernesniemi , J 2019 , ' Pineoblastomas : A long-term follow up study of three cases in Helsinki Neurosurgery ' , Interdisciplinary neurosurgery: advanced techniques and case management , vol. 18 , 100477 . https://doi.org/10.1016/j.inat.2019.100477

Titel: Pineoblastomas : A long-term follow up study of three cases in Helsinki Neurosurgery
Författare: Choque-Velasquez, Joham; Resendiz-Nieves, Julio C.; Jahromi, Behnam Rezai; Colasanti, Roberto; Tynninen, Olli; Collan, Juhani; Niemelä, Mika; Hernesniemi, Juha
Upphovmannens organisation: Clinicum
HUS Neurocenter
Neurokirurgian yksikkö
University of Helsinki
Medicum
HUSLAB
Department of Pathology
HUS Comprehensive Cancer Center
Department of Oncology
Department of Neurosciences
Datum: 2019-12
Språk: eng
Sidantal: 5
Tillhör serie: Interdisciplinary neurosurgery: advanced techniques and case management
ISSN: 2214-7519
DOI: https://doi.org/10.1016/j.inat.2019.100477
Permanenta länken (URI): http://hdl.handle.net/10138/307926
Abstrakt: Background Pineoblastomas are very rare malignant lesions with a bad prognosis and high mortality during the first five years from diagnosis. Report of cases We present a retrospective review of three patients with histologically confirmed pineoblastomas consecutively operated on between 1997 and 2015. One of our patients died >14 years after surgery, and the other 2 patients are still alive and in good condition without recurrence of the disease >12 years after surgery. All of them underwent gross total resection and craniospinal radiotherapy. Individualized scheme of chemotherapy was administered in two cases. The cornerstones for the surgical resection of pineoblastomas are reported. Conclusions A proper multidisciplinary management of pineoblastomas, which associates gross total microsurgical resection of the lesion and an adjuvant therapy determined by our neurooncology team based on accurate craniospinal adjuvant radiotherapy with boost of radiation on the tumoral bed, and when needed, an adequate but aggressive medulloblastoma-like chemotherapy, may improve the overall survival of these malignant lesions.
Subject: 3112 Neurosciences
3124 Neurology and psychiatry
3126 Surgery, anesthesiology, intensive care, radiology
Chemotherapy
Microneurosurgery
Pineal region lesions
Pineoblastomas
Radiotherapy
Sitting position
Supracerebellar infratentorial approach
HEALTH-ORGANIZATION CLASSIFICATION
SURVIVAL
PINEAL REGION TUMORS
CENTRAL-NERVOUS-SYSTEM
FEATURES
Referentgranskad: Ja
Licens: cc_by_nc_nd
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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