Pineoblastomas : A long-term follow up study of three cases in Helsinki Neurosurgery

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dc.contributor.author Choque-Velasquez, Joham
dc.contributor.author Resendiz-Nieves, Julio C.
dc.contributor.author Jahromi, Behnam Rezai
dc.contributor.author Colasanti, Roberto
dc.contributor.author Tynninen, Olli
dc.contributor.author Collan, Juhani
dc.contributor.author Niemelä, Mika
dc.contributor.author Hernesniemi, Juha
dc.date.accessioned 2019-12-04T22:30:00Z
dc.date.available 2019-12-04T22:30:00Z
dc.date.issued 2019-12
dc.identifier.citation Choque-Velasquez , J , Resendiz-Nieves , J C , Jahromi , B R , Colasanti , R , Tynninen , O , Collan , J , Niemelä , M & Hernesniemi , J 2019 , ' Pineoblastomas : A long-term follow up study of three cases in Helsinki Neurosurgery ' , Interdisciplinary neurosurgery: advanced techniques and case management , vol. 18 , 100477 . https://doi.org/10.1016/j.inat.2019.100477
dc.identifier.other PURE: 127338997
dc.identifier.other PURE UUID: 414735fb-d6cc-4957-9fa3-ac4ea59bad9d
dc.identifier.other RIS: urn:D8DC40A9CB144F994A9ED26F63667C67
dc.identifier.other ORCID: /0000-0003-3937-2816/work/65675000
dc.identifier.other WOS: 000499495300039
dc.identifier.other ORCID: /0000-0001-5220-1216/work/66368002
dc.identifier.uri http://hdl.handle.net/10138/307926
dc.description.abstract Background Pineoblastomas are very rare malignant lesions with a bad prognosis and high mortality during the first five years from diagnosis. Report of cases We present a retrospective review of three patients with histologically confirmed pineoblastomas consecutively operated on between 1997 and 2015. One of our patients died >14 years after surgery, and the other 2 patients are still alive and in good condition without recurrence of the disease >12 years after surgery. All of them underwent gross total resection and craniospinal radiotherapy. Individualized scheme of chemotherapy was administered in two cases. The cornerstones for the surgical resection of pineoblastomas are reported. Conclusions A proper multidisciplinary management of pineoblastomas, which associates gross total microsurgical resection of the lesion and an adjuvant therapy determined by our neurooncology team based on accurate craniospinal adjuvant radiotherapy with boost of radiation on the tumoral bed, and when needed, an adequate but aggressive medulloblastoma-like chemotherapy, may improve the overall survival of these malignant lesions. en
dc.format.extent 5
dc.language.iso eng
dc.relation.ispartof Interdisciplinary neurosurgery: advanced techniques and case management
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.subject Chemotherapy
dc.subject Microneurosurgery
dc.subject Pineal region lesions
dc.subject Pineoblastomas
dc.subject Radiotherapy
dc.subject Sitting position
dc.subject Supracerebellar infratentorial approach
dc.subject HEALTH-ORGANIZATION CLASSIFICATION
dc.subject SURVIVAL
dc.subject PINEAL REGION TUMORS
dc.subject CENTRAL-NERVOUS-SYSTEM
dc.subject FEATURES
dc.title Pineoblastomas : A long-term follow up study of three cases in Helsinki Neurosurgery en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization HUS Neurocenter
dc.contributor.organization Neurokirurgian yksikkö
dc.contributor.organization University of Helsinki
dc.contributor.organization Medicum
dc.contributor.organization HUSLAB
dc.contributor.organization Department of Pathology
dc.contributor.organization HUS Comprehensive Cancer Center
dc.contributor.organization Department of Oncology
dc.contributor.organization Department of Neurosciences
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.inat.2019.100477
dc.relation.issn 2214-7519
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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