The Prevalence of HSV, HHV-6, HPV and Mycoplasma genitalium in Chlamydia trachomatis positive and Chlamydia trachomatis Negative Urogenital Samples among Young Women in Finland

Show full item record



Permalink

http://hdl.handle.net/10138/307985

Citation

Korhonen, S.; Hokynar, K.; Eriksson, T.; Natunen, K.; Paavonen, J.; Lehtinen, M.; Puolakkainen, M. The Prevalence of HSV, HHV-6, HPV and Mycoplasma genitalium in Chlamydia trachomatis positive and Chlamydia trachomatis Negative Urogenital Samples among Young Women in Finland. Pathogens 2019, 8, 276.

Title: The Prevalence of HSV, HHV-6, HPV and Mycoplasma genitalium in Chlamydia trachomatis positive and Chlamydia trachomatis Negative Urogenital Samples among Young Women in Finland
Author: Korhonen, Suvi; Hokynar, Kati; Eriksson, Tiina; Natunen, Kari; Paavonen, Jorma; Lehtinen, Matti; Puolakkainen, Mirja
Publisher: Multidisciplinary Digital Publishing Institute
Date: 2019-12-01
URI: http://hdl.handle.net/10138/307985
Abstract: <i>Chlamydia trachomatis</i>, <i>Mycoplasma genitalium</i>, herpes simplex virus (HSV) and human papillomavirus (HPV) cause sexually transmitted infections. In addition, human herpesvirus 6 (HHV-6) may be a genital co-pathogen. The prevalence rates of HSV, HHV-6, HPV,<i> M. genitalium</i>, and the <i>C. trachomatis ompA</i> genotypes were investigated by PCR in urogenital samples of the <i>C. trachomatis</i> nucleic acid amplification test positive (n = 157) and age-, community- and time-matched negative (n = 157) women. The prevalence of HPV DNA was significantly higher among the <i>C. trachomatis</i> positives than the <i>C. trachomatis</i> negatives (66% vs. 25%, <i>p </i>&lt;<i> </i>0.001). The prevalence of HSV (1.9% vs. 0%), HHV-6 (11% vs. 14%), and <i>M. genitalium</i> DNA (4.5% vs. 1.9%) was not significantly different between the <i>C. trachomatis</i>-positive and -negative women. Thirteen per cent of test-of-cure specimens tested positive for <i>C. trachomatis</i>. The prevalence of HSV, HHV-6, HPV, <i>M. genitalium</i>, and the <i>C. trachomatis ompA</i> genotypes did not significantly differ between those who cleared the <i>C. trachomatis</i> infection (n = 105) and those who did not (n = 16). The higher prevalence of HPV DNA among the <i>C. trachomatis</i> positives suggests greater sexual activity and increased risk for sexually transmitted pathogens.


Files in this item

Total number of downloads: Loading...

Files Size Format View
pathogens-08-00276.pdf 312.7Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record