Bioimpedance analysis and physical functioning as mortality indicators among older sarcopenic people

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http://hdl.handle.net/10138/308319

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Bjorkman , M P , Pitkala , K H , Jyvakorpi , S , Strandberg , T E & Tilvis , R S 2019 , ' Bioimpedance analysis and physical functioning as mortality indicators among older sarcopenic people ' , Experimental Gerontology , vol. 122 , pp. 42-46 . https://doi.org/10.1016/j.exger.2019.04.012

Titel: Bioimpedance analysis and physical functioning as mortality indicators among older sarcopenic people
Författare: Bjorkman, Mikko P.; Pitkala, Kaisu H.; Jyvakorpi, Satu; Strandberg, Timo E.; Tilvis, Reijo S.
Upphovmannens organisation: Department of Medicine
Clinicum
HUS Internal Medicine and Rehabilitation
Helsinki University Hospital Area
Department of General Practice and Primary Health Care
Timo Strandberg / Principal Investigator
Teachers' Academy
Datum: 2019-07-15
Språk: eng
Sidantal: 5
Tillhör serie: Experimental Gerontology
ISSN: 0531-5565
DOI: https://doi.org/10.1016/j.exger.2019.04.012
Permanenta länken (URI): http://hdl.handle.net/10138/308319
Abstrakt: Objectives: To assess the prognostic significance of various characteristics and measurements of sarcopenia and physical functioning on all-cause mortality among home-dwelling older people with or at-risk of sarcopenia. Design: Cross-sectional and longitudinal analyses. Setting: Porvoo sarcopenia trial in open care. Participants: Community-dwelling people aged 75 and older (N = 428, of which 182 were re-examined at one year) with four years of follow-up. Measurements: Body mass index (BMI), physical functioning (physical component of the RAND-36) and physical performance tests (Short Physical Performance Battery (SPPB)), hand grip strength, walking speed, Charlson Comorbity Index, bioimpedance-based surrogates for muscle mass: Single Frequency Skeletal Muscle Index (SF-SMI), and Calf Intracellular Resistance Skeletal Muscle Index (CRi-SMI). Date of death was retrieved from central registers. Survival analyses were performed using Life-Table analyses and Cox models. Results: Most test variables (except BMI) were associated with four-year mortality in a dose-dependent fashion. After controlling for age, gender and co-morbidity, physical performance and functioning (both SPPB and RAND36), muscle strength (hand grip strength) and CRi-SMI appeared to be independent mortality risk indicators (p <0.001) whereas SF-SMI was not. When CRi-SMI values were grouped by gender-specific cut-off points, the probability of surviving for four years decreased by 66% among the older people with low CRi-SMI (HR = 0.34, 95%CI 0.15-0.78, p = 0.011). When low CRi-SMI was further controlled for SPPB, the prognostic significance remained significant (HR = 0.55, 95%CI 0.33-0.92, p = 0.021). After controlling for age, gender, comorbidity, and CRi-SMI, the physical component of the RAND-36 (p = 0.007), SPPB (p <0,001) and hand grip strength (p = 0.009) remained significant mortality predictors. Twelve-month changes were similarly associated with allcause mortality during the follow-up period. Conclusion: CRi-SMI, muscle strength, physical performance and physical functioning are each strong independent predictors of all-cause mortality among home-dwelling older people. Compared to these indicators, BMI seemed to be clearly inferior. Of two bioimpedance-based muscle indices, CRi SMI was better predictor of mortality than SF-SMI. In this regard, muscle mass, muscle strength and physical performance are all suitable targets for the prevention of sarcopenia-related over-mortality.
Subject: Sarcopenia
Bioimpedance analysis
Physical functioning
Survival prognosis
SKELETAL-MUSCLE MASS
BIOELECTRICAL-IMPEDANCE
INDEPENDENT PREDICTOR
BODY-COMPOSITION
WEIGHT-LOSS
OBESITY
SPECTROSCOPY
ASSOCIATION
PERFORMANCE
STRENGTH
3121 General medicine, internal medicine and other clinical medicine
Referentgranskad: Ja
Licens: cc_by_nc_nd
Användningsbegränsning: openAccess
Parallelpublicerad version: acceptedVersion


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