Bioimpedance analysis and physical functioning as mortality indicators among older sarcopenic people

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dc.contributor.author Bjorkman, Mikko P.
dc.contributor.author Pitkala, Kaisu H.
dc.contributor.author Jyvakorpi, Satu
dc.contributor.author Strandberg, Timo E.
dc.contributor.author Tilvis, Reijo S.
dc.date.accessioned 2019-12-13T22:43:10Z
dc.date.available 2021-12-17T22:45:39Z
dc.date.issued 2019-07-15
dc.identifier.citation Bjorkman , M P , Pitkala , K H , Jyvakorpi , S , Strandberg , T E & Tilvis , R S 2019 , ' Bioimpedance analysis and physical functioning as mortality indicators among older sarcopenic people ' , Experimental Gerontology , vol. 122 , pp. 42-46 . https://doi.org/10.1016/j.exger.2019.04.012
dc.identifier.other PURE: 125145363
dc.identifier.other PURE UUID: 33b60664-2fe4-4299-a739-7b159500a596
dc.identifier.other WOS: 000468876200006
dc.identifier.other ORCID: /0000-0001-9659-6985/work/58509769
dc.identifier.other ORCID: /0000-0001-6299-925X/work/58510862
dc.identifier.other ORCID: /0000-0001-5901-3584/work/68618549
dc.identifier.uri http://hdl.handle.net/10138/308319
dc.description.abstract Objectives: To assess the prognostic significance of various characteristics and measurements of sarcopenia and physical functioning on all-cause mortality among home-dwelling older people with or at-risk of sarcopenia. Design: Cross-sectional and longitudinal analyses. Setting: Porvoo sarcopenia trial in open care. Participants: Community-dwelling people aged 75 and older (N = 428, of which 182 were re-examined at one year) with four years of follow-up. Measurements: Body mass index (BMI), physical functioning (physical component of the RAND-36) and physical performance tests (Short Physical Performance Battery (SPPB)), hand grip strength, walking speed, Charlson Comorbity Index, bioimpedance-based surrogates for muscle mass: Single Frequency Skeletal Muscle Index (SF-SMI), and Calf Intracellular Resistance Skeletal Muscle Index (CRi-SMI). Date of death was retrieved from central registers. Survival analyses were performed using Life-Table analyses and Cox models. Results: Most test variables (except BMI) were associated with four-year mortality in a dose-dependent fashion. After controlling for age, gender and co-morbidity, physical performance and functioning (both SPPB and RAND36), muscle strength (hand grip strength) and CRi-SMI appeared to be independent mortality risk indicators (p <0.001) whereas SF-SMI was not. When CRi-SMI values were grouped by gender-specific cut-off points, the probability of surviving for four years decreased by 66% among the older people with low CRi-SMI (HR = 0.34, 95%CI 0.15-0.78, p = 0.011). When low CRi-SMI was further controlled for SPPB, the prognostic significance remained significant (HR = 0.55, 95%CI 0.33-0.92, p = 0.021). After controlling for age, gender, comorbidity, and CRi-SMI, the physical component of the RAND-36 (p = 0.007), SPPB (p <0,001) and hand grip strength (p = 0.009) remained significant mortality predictors. Twelve-month changes were similarly associated with allcause mortality during the follow-up period. Conclusion: CRi-SMI, muscle strength, physical performance and physical functioning are each strong independent predictors of all-cause mortality among home-dwelling older people. Compared to these indicators, BMI seemed to be clearly inferior. Of two bioimpedance-based muscle indices, CRi SMI was better predictor of mortality than SF-SMI. In this regard, muscle mass, muscle strength and physical performance are all suitable targets for the prevention of sarcopenia-related over-mortality. en
dc.format.extent 5
dc.language.iso eng
dc.relation.ispartof Experimental Gerontology
dc.rights cc_by_nc_nd
dc.rights unspecified
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Sarcopenia
dc.subject Bioimpedance analysis
dc.subject Physical functioning
dc.subject Survival prognosis
dc.subject SKELETAL-MUSCLE MASS
dc.subject BIOELECTRICAL-IMPEDANCE
dc.subject INDEPENDENT PREDICTOR
dc.subject BODY-COMPOSITION
dc.subject WEIGHT-LOSS
dc.subject OBESITY
dc.subject SPECTROSCOPY
dc.subject ASSOCIATION
dc.subject PERFORMANCE
dc.subject STRENGTH
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Bioimpedance analysis and physical functioning as mortality indicators among older sarcopenic people en
dc.type Article
dc.contributor.organization Department of Medicine
dc.contributor.organization Clinicum
dc.contributor.organization HUS Internal Medicine and Rehabilitation
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization Department of General Practice and Primary Health Care
dc.contributor.organization Timo Strandberg / Principal Investigator
dc.contributor.organization Teachers' Academy
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.exger.2019.04.012
dc.relation.issn 0531-5565
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion
dc.type.version publishedVersion

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