Fat oxidation at rest and during exercise in male monozygotic twins

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http://hdl.handle.net/10138/308429

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Karppinen , J E , Rottensteiner , M , Wiklund , P , Hamalainen , K , Laakkonen , E K , Kaprio , J , Kainulainen , H & Kujala , U M 2019 , ' Fat oxidation at rest and during exercise in male monozygotic twins ' , European Journal of Applied Physiology , vol. 119 , no. 11-12 , pp. 2711-2722 . https://doi.org/10.1007/s00421-019-04247-x

Title: Fat oxidation at rest and during exercise in male monozygotic twins
Author: Karppinen, Jari E.; Rottensteiner, Mirva; Wiklund, Petri; Hamalainen, Kaisa; Laakkonen, Eija K.; Kaprio, Jaakko; Kainulainen, Heikki; Kujala, Urho M.
Other contributor: University of Helsinki, Institute for Molecular Medicine Finland

Date: 2019-12
Language: eng
Number of pages: 12
Belongs to series: European Journal of Applied Physiology
ISSN: 1439-6319
DOI: https://doi.org/10.1007/s00421-019-04247-x
URI: http://hdl.handle.net/10138/308429
Abstract: Purpose We aimed to investigate if hereditary factors, leisure-time physical activity (LTPA) and metabolic health interact with resting fat oxidation (RFO) and peak fat oxidation (PFO) during ergometer cycling. Methods We recruited 23 male monozygotic twin pairs (aged 32-37 years) and determined their RFO and PFO with indirect calorimetry for 21 and 19 twin pairs and for 43 and 41 twin individuals, respectively. Using physical activity interviews and the Baecke questionnaire, we identified 10 twin pairs as LTPA discordant for the past 3 years. Of the twin pairs, 8 pairs participated in both RFO and PFO measurements, and 2 pairs participated in either of the measurements. We quantified the participants' metabolic health with a 2-h oral glucose tolerance test. Results Fat oxidation within co-twins was correlated at rest [intraclass correlation coefficient (ICC) = 0.54, 95% confidence interval (CI) 0.15-0.78] and during exercise (ICC = 0.67, 95% CI 0.33-0.86). The LTPA-discordant pairs had no pairwise differences in RFO or PFO. In the twin individual-based analysis, PFO was positively correlated with the past 12-month LTPA (r = 0.26, p = 0.034) and the Baecke score (r = 0.40, p = 0.022) and negatively correlated with the area under the curve of insulin (r = - 0.42, p = 0.015) and glucose (r = - 0.31, p = 0.050) during the oral glucose tolerance test. Conclusions Hereditary factors were more important than LTPA for determining fat oxidation at rest and during exercise. Additionally, PFO, but not RFO, was associated with better metabolic health.
Subject: Twins
Exercise
Lipid metabolism
Oral glucose tolerance
TIME PHYSICAL-ACTIVITY
INSULIN SENSITIVITY
SUBSTRATE OXIDATION
DIETARY-FAT
INTENSITY
CARBOHYDRATE
CAPACITY
YOUNG
DETERMINANTS
VARIABILITY
1184 Genetics, developmental biology, physiology
315 Sport and fitness sciences
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