Introducing a novel gravitation-based high-velocity compaction analysis method for pharmaceutical powders

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Tanner , T , Antikainen , O , Ehlers , H & Yliruusi , J 2017 , ' Introducing a novel gravitation-based high-velocity compaction analysis method for pharmaceutical powders ' , International Journal of Pharmaceutics , vol. 526 , no. 1-2 , pp. 31-40 . https://doi.org/10.1016/j.ijpharm.2017.04.039

Title: Introducing a novel gravitation-based high-velocity compaction analysis method for pharmaceutical powders
Author: Tanner, Timo; Antikainen, Osmo; Ehlers, Henrik; Yliruusi, Jouko
Contributor organization: Faculty of Pharmacy
University of Helsinki
Division of Pharmaceutical Chemistry and Technology
Preclinical Drug Formulation and Analysis group
Division of Pharmaceutical Technology (-2019)
Jouko Yliruusi / Principal Investigator
Drug Research Program
Date: 2017-06-30
Language: eng
Number of pages: 10
Belongs to series: International Journal of Pharmaceutics
ISSN: 0378-5173
DOI: https://doi.org/10.1016/j.ijpharm.2017.04.039
URI: http://hdl.handle.net/10138/308430
Abstract: With modern tableting machines large amounts of tablets are produced with high output. Consequently, methods to examine powder compression in a high-velocity setting are in demand. In the present study, a novel gravitation-based method was developed to examine powder compression. A steel bar is dropped on a punch to compress microcrystalline cellulose and starch samples inside the die. The distance of the bar is being read by a high-accuracy laser displacement sensor which provides a reliable distance-time plot for the bar movement. In-die height and density of the compact can be seen directly from this data, which can be examined further to obtain information on velocity, acceleration and energy distribution during compression. The energy consumed in compact formation could also be seen. Despite the high vertical compression speed, the method was proven to be cost-efficient, accurate and reproducible. (C) 2017 Elsevier B.V. All rights reserved.
Subject: Tabletting
Compaction
Compression
Viscoelasticity
Microcrystalline cellulose
Starch
MICROCRYSTALLINE CELLULOSE
COMPRESSION
TABLETS
TEMPERATURE
STRENGTH
BEHAVIOR
317 Pharmacy
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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