Tanner , T , Antikainen , O , Ehlers , H & Yliruusi , J 2017 , ' Introducing a novel gravitation-based high-velocity compaction analysis method for pharmaceutical powders ' , International Journal of Pharmaceutics , vol. 526 , no. 1-2 , pp. 31-40 . https://doi.org/10.1016/j.ijpharm.2017.04.039
Title: | Introducing a novel gravitation-based high-velocity compaction analysis method for pharmaceutical powders |
Author: | Tanner, Timo; Antikainen, Osmo; Ehlers, Henrik; Yliruusi, Jouko |
Contributor organization: | Faculty of Pharmacy University of Helsinki Division of Pharmaceutical Chemistry and Technology Preclinical Drug Formulation and Analysis group Division of Pharmaceutical Technology (-2019) Jouko Yliruusi / Principal Investigator Drug Research Program |
Date: | 2017-06-30 |
Language: | eng |
Number of pages: | 10 |
Belongs to series: | International Journal of Pharmaceutics |
ISSN: | 0378-5173 |
DOI: | https://doi.org/10.1016/j.ijpharm.2017.04.039 |
URI: | http://hdl.handle.net/10138/308430 |
Abstract: | With modern tableting machines large amounts of tablets are produced with high output. Consequently, methods to examine powder compression in a high-velocity setting are in demand. In the present study, a novel gravitation-based method was developed to examine powder compression. A steel bar is dropped on a punch to compress microcrystalline cellulose and starch samples inside the die. The distance of the bar is being read by a high-accuracy laser displacement sensor which provides a reliable distance-time plot for the bar movement. In-die height and density of the compact can be seen directly from this data, which can be examined further to obtain information on velocity, acceleration and energy distribution during compression. The energy consumed in compact formation could also be seen. Despite the high vertical compression speed, the method was proven to be cost-efficient, accurate and reproducible. (C) 2017 Elsevier B.V. All rights reserved. |
Subject: |
Tabletting
Compaction Compression Viscoelasticity Microcrystalline cellulose Starch MICROCRYSTALLINE CELLULOSE COMPRESSION TABLETS TEMPERATURE STRENGTH BEHAVIOR 317 Pharmacy |
Peer reviewed: | Yes |
Rights: | cc_by_nc_nd |
Usage restriction: | openAccess |
Self-archived version: | acceptedVersion |
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