Systemic inflammatory response to shoulder ulcers and lack of preventive effect of postpartum pain medication with ketoprofen in sows

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Nystén , M , Orro , T & Peltoniemi , O 2018 , ' Systemic inflammatory response to shoulder ulcers and lack of preventive effect of postpartum pain medication with ketoprofen in sows ' , Livestock Science , vol. 214 , pp. 9-17 . https://doi.org/10.1016/j.livsci.2018.04.019

Title: Systemic inflammatory response to shoulder ulcers and lack of preventive effect of postpartum pain medication with ketoprofen in sows
Author: Nystén, Maria; Orro, Toomas; Peltoniemi, Olli
Contributor: University of Helsinki, Faculty of Veterinary Medicine
University of Helsinki, Estonian University of Life Sciences
University of Helsinki, Production Animal Medicine
Date: 2018-05-10
Language: eng
Number of pages: 9
Belongs to series: Livestock Science
ISSN: 1871-1413
URI: http://hdl.handle.net/10138/308490
Abstract: Shoulder lesions are common in lactating sows and can affect their welfare. We assessed the systemic inflammatory response to shoulder ulcers and monitored the preventive effect of postpartum administration with non-steroidal anti-inflammatory medication (ketoprofen) on their prevalence. In a double-blind placebo-controlled field trial, 144 YxL hybrid sows farrowing in crates with a cast-iron floor received either ketoprofen (3 mg/kg) or placebo as an intramuscular injection on days 0-1 after parturition. During the lactation period (weeks 1–4) all sows were assessed weekly for the presence of shoulder ulcers (0 = no ulcer, 1 = unilateral ulcer, 2 = bilateral ulcers; in all cases at least epithelial damage). From a subset of 37 sows, haptoglobin (Hp), albumin (ALB) and cortisol (COR) were measured from blood samples taken 10 to 12 days after farrowing. Results were analyzed according to a linear regression model for associations between Hp, ALB, COR and shoulder ulcers. A random ordered logistic model was used to assess risk factors (body condition score (BCS), back and shoulder fat, decrease in BCS or fat layer thickness during lactation, parity, number of live born and stillborn piglets, piglets weaned, shoulder ulcer scar) and the effect of ketoprofen treatment. Total prevalence of shoulder ulcers at lactation weeks 1–4 was 26.4%, 33.3%, 38.2% and 38.9%, respectively. Prevalences of unilateral shoulder ulcers at lactation weeks 1–4 were 16.7%, 19.4%, 20.8% and 18.8%, and prevalences of bilateral shoulder ulcers were 9.7%, 13.9%, 17.4%, and 20.1%. There was a decrease in albumin and an increase in Hp levels in sows with bilateral shoulder ulcers compared with sows without shoulder ulcers (P 
Subject: Sow
Shoulder ulcer
Ketoprofen
Systemic response
Welfare
ACUTE-PHASE PROTEINS
POSTMORTEM MEAT-INSPECTION
DECUBITAL ULCERS
RISK-FACTORS
SERUM HAPTOGLOBIN
EARLY LACTATION
FARROWING SOWS
DANISH SOWS
BEHAVIOR
PIGS
413 Veterinary science
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