The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood

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Savonius , O , Roine , I , Alassiri , S , Tervahartiala , T , Helve , O , Fernandez , J , Peltola , H , Sorsa , T & Pelkonen , T 2019 , ' The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood ' , Mediators of Inflammation , vol. 2019 , 7436932 . https://doi.org/10.1155/2019/7436932

Title: The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood
Author: Savonius, Okko; Roine, Irmeli; Alassiri, Saeed; Tervahartiala, Taina; Helve, Otto; Fernandez, Josefina; Peltola, Heikki; Sorsa, Timo; Pelkonen, Tuula
Contributor organization: HUS Children and Adolescents
Children's Hospital
University of Helsinki
Department of Oral and Maxillofacial Diseases
HUS Head and Neck Center
University Management
Clinicum
Staff Services
Lastentautien yksikkö
Timo Sorsa / Principal Investigator
Suu- ja leukakirurgian yksikkö
Date: 2019-11-03
Language: eng
Number of pages: 8
Belongs to series: Mediators of Inflammation
ISSN: 0962-9351
DOI: https://doi.org/10.1155/2019/7436932
URI: http://hdl.handle.net/10138/308550
Abstract: Background. Matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) contribute to the inflammatory cascade in the cerebrospinal fluid (CSF) during bacterial meningitis. We determined levels of MPO, MMP-8, MMP-9, and tissue inhibitor of metalloproteinase- (TIMP-) 1 in the CSF of children with bacterial meningitis and investigated how these inflammatory mediators relate to each other and to the disease outcomes. Methods. Clinical data and the diagnostic CSF samples from 245 children (median age eight months) with bacterial meningitis were obtained from a clinical trial in Latin America in 1996-2003. MMP-9 levels in the CSF were assessed by zymography, while MMP-8, MPO, and TIMP-1 concentrations were determined with immunofluorometric and enzyme-linked immunosorbent assays. Results. MPO correlated positively with MMP-8 (rho 0.496, P
Subject: CEREBROSPINAL-FLUID
ACTIVATION
MMP-9
MATRIX-METALLOPROTEINASE-9
INFLAMMATION
INHIBITORS
TIMP-1
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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