Copy-number variation of housekeeping gene rpl13a in the hippocampus and bone marrow of rat strains selected for nervous system excitability

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dc.contributor.author Kalendar, Ruslan
dc.contributor.author Belyaev, Alexander
dc.contributor.author Zachepilo, Tatiana
dc.contributor.author Maidanyuk, Dmitry
dc.contributor.author Vaido, Alexander
dc.contributor.author Schulman, Alan
dc.contributor.author Dyuzhikova, Natalia
dc.date.accessioned 2019-12-20T08:57:01Z
dc.date.available 2019-12-20T08:57:01Z
dc.date.issued 2017-02-10
dc.identifier.citation Kalendar , R , Belyaev , A , Zachepilo , T , Maidanyuk , D , Vaido , A , Schulman , A & Dyuzhikova , N 2017 , ' Copy-number variation of housekeeping gene rpl13a in the hippocampus and bone marrow of rat strains selected for nervous system excitability ' , Molecular and Cellular Probes , vol. 33 , pp. 11-15 . https://doi.org/10.1016/j.mcp.2017.02.004
dc.identifier.other PURE: 46534664
dc.identifier.other PURE UUID: 9a48b076-bd35-4d1e-810f-fde73d49b622
dc.identifier.other Scopus: 85012879206
dc.identifier.other WOS: 000403193100004
dc.identifier.other ORCID: /0000-0003-3986-2460/work/43649564
dc.identifier.uri http://hdl.handle.net/10138/308663
dc.description.abstract Genomic structural differences among individuals, particularly copy number variation (CNV), are of great importance in the exploration of mammalian diversity and evolution. CNV is implicated in diverse human diseases including nervous system, neurological, and autoimmune disorders. Here, we aimed to detect and evaluate CNV for four genes: grin1 that is multifunctional in the regulation of normal and pathological brain functions; three housekeeping genes with stable expression, gapdh, rpl13a, and ywhaz. These were examined in rat strains differing in excitability of the nervous systems. The rpl13a copy number is significantly reduced in both the hippocampus and bone marrow in rats with a high excitability threshold (HT). In bone marrow of rats with a low excitability threshold (LT), there is a two fold increase in the rpl13a copy numbervs Wistar rats. Stress is also connected to a decrease rpl13a copy number in the bone marrow of HT ( emotional hypokinetic stress) and Wistar rats (emotional painful stress). The observed phenomenon may be associated with the role of rpl13 a in lipid metabolism; synaptic membranes of the HT cerebral cortex had significantly higher amounts of sphingomyelin and phosphatidylcholine. en
dc.language.iso eng
dc.relation.ispartof Molecular and Cellular Probes
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 1182 Biochemistry, cell and molecular biology
dc.title Copy-number variation of housekeeping gene rpl13a in the hippocampus and bone marrow of rat strains selected for nervous system excitability en
dc.type Article
dc.contributor.organization Institute of Biotechnology
dc.contributor.organization Viikki Plant Science Centre (ViPS)
dc.contributor.organization Alan Schulman / Principal Investigator
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.mcp.2017.02.004
dc.relation.issn 0890-8508
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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