Improved synthesis of [18F] fallypride and characterization of a Huntington’s disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2/D3 receptors

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Huhtala , T , Poutiainen , P , Rytkönen , J , Lehtimäki , K , Parkkari , T , Kasanen , I , Airaksinen , A J , Koivula , T , Sweeney , P , Kontkanen , O , Wityak , J , Dominiquez , C & Park , L C 2019 , ' Improved synthesis of [18F] fallypride and characterization of a Huntington’s disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2/D3 receptors ' , EJNMMI Radiopharmacy and Chemistry , vol. 4 , no. 1 . https://doi.org/10.1186/s41181-019-0071-6

Title: Improved synthesis of [18F] fallypride and characterization of a Huntington’s disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2/D3 receptors
Author: Huhtala, Tuulia; Poutiainen, Pekka; Rytkönen, Jussi; Lehtimäki, Kimmo; Parkkari, Teija; Kasanen, Iiris; Airaksinen, Anu J.; Koivula, Teija; Sweeney, Patrick; Kontkanen, Outi; Wityak, John; Dominiquez, Celia; Park, Larry C.
Contributor: University of Helsinki, Department of Chemistry
University of Helsinki, Department of Chemistry
Date: 2019-08-05
Language: eng
Number of pages: 10
Belongs to series: EJNMMI Radiopharmacy and Chemistry
ISSN: 2365-421X
URI: http://hdl.handle.net/10138/308666
Abstract: Dopamine receptors are involved in pathophysiology of neuropsychiatric diseases, including Huntington’s disease (HD). PET imaging of dopamine D2 receptors (D2R) in HD patients has demonstrated 40% decrease in D2R binding in striatum, and D2R could be a reliable quantitative target to monitor disease progression. A D2/3R antagonist, [18F] fallypride, is a high-affinity radioligand that has been clinically used to study receptor density and occupancy in neuropsychiatric disorders. Here we report an improved synthesis method for [18F]fallypride. In addition, high molar activity of the ligand has allowed us to apply PET imaging to characterize D2/D3 receptor density in striatum of the recently developed zQ175DN knock-in (KI) mouse model of HD.
Subject: 317 Pharmacy
116 Chemical sciences
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