Site-Specific 111In-Radiolabeling of Dual-PEGylated Porous Silicon Nanoparticles and Their In Vivo Evaluation in Murine 4T1 Breast Cancer Model

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dc.contributor.author Lumen, Dave
dc.contributor.author Näkki, Simo
dc.contributor.author Imlimthan, Surachet
dc.contributor.author Lambidis, Elisavet
dc.contributor.author Sarparanta, Mirkka
dc.contributor.author Xu, Wujun
dc.contributor.author Lehto, Vesa-Pekka
dc.contributor.author Airaksinen, Anu J.
dc.date.accessioned 2019-12-20T14:10:32Z
dc.date.available 2019-12-20T14:10:32Z
dc.date.issued 2019-12-17
dc.identifier.citation Lumen, D.; Näkki, S.; Imlimthan, S.; Lambidis, E.; Sarparanta, M.; Xu, W.; Lehto, V.-P.; Airaksinen, A.J. Site-Specific 111In-Radiolabeling of Dual-PEGylated Porous Silicon Nanoparticles and Their In Vivo Evaluation in Murine 4T1 Breast Cancer Model. Pharmaceutics 2019, 11, 686.
dc.identifier.uri http://hdl.handle.net/10138/308693
dc.description.abstract Polyethylene glycol (PEG) has been successfully used for improving circulation time of several nanomaterials but prolonging the circulation of porous silicon nanoparticles (PSi NPs) has remained challenging. Here, we report a site specific radiolabeling of dual-PEGylated thermally oxidized porous silicon (DPEG-TOPSi) NPs and investigation of influence of the PEGylation on blood circulation time of TOPSi NPs. <i>Trans</i>-cyclooctene conjugated DPEG-TOPSi NPs were radiolabeled through a click reaction with [<sup>111</sup>In]In-DOTA-PEG<sub>4</sub>-tetrazine (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and the particle behavior was evaluated in vivo in Balb/c mice bearing 4T1 murine breast cancer allografts. The dual-PEGylation significantly prolonged circulation of [<sup>111</sup>In]In-DPEG-TOPSi particles when compared to non-PEGylated control particles, yielding 10.8 &plusmn; 1.7% of the injected activity/g in blood at 15 min for [<sup>111</sup>In]In-DPEG-TOPSi NPs. The improved circulation time will be beneficial for the accumulation of targeted DPEG-TOPSi to tumors.
dc.publisher Multidisciplinary Digital Publishing Institute
dc.title Site-Specific 111In-Radiolabeling of Dual-PEGylated Porous Silicon Nanoparticles and Their In Vivo Evaluation in Murine 4T1 Breast Cancer Model
dc.date.updated 2019-12-20T14:10:32Z
dc.type.uri http://purl.org/eprint/entityType/JournalArticle
dc.type.uri http://purl.org/eprint/entityType/Expression
dc.type.uri http://purl.org/eprint/entityType/Expression

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