Foramen ovale blood flow and cardiac function after main pulmonary artery occlusion in fetal sheep

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Lantto , J , Erkinaro , T , Haapsamo , M , Huhta , H , Voipio , H-M , Hohimer , A R , Davis , L E , Acharya , G & Räsänen , J 2019 , ' Foramen ovale blood flow and cardiac function after main pulmonary artery occlusion in fetal sheep ' , Experimental Physiology , vol. 104 , no. 2 , pp. 189-198 .

Title: Foramen ovale blood flow and cardiac function after main pulmonary artery occlusion in fetal sheep
Author: Lantto, Juulia; Erkinaro, Tiina; Haapsamo, Mervi; Huhta, Heikki; Voipio, Hanna-Marja; Hohimer, A. Roger; Davis, Lowell E.; Acharya, Ganesh; Räsänen, Juha
Contributor organization: Department of Obstetrics and Gynecology
HUS Gynecology and Obstetrics
Date: 2019-02
Language: eng
Number of pages: 10
Belongs to series: Experimental Physiology
ISSN: 0958-0670
Abstract: The foramen ovale (FO) accounts for the majority of fetal left ventricular (LV) output. Increased right ventricular afterload can cause a redistribution of combined cardiac output between the ventricles. To understand the capability of the FO to increase its volume blood flow and thus LV output, we mechanically occluded the main pulmonary artery in seven chronically instrumented near-term sheep fetuses. We hypothesized that FO volume blood flow and LV output would increase during main pulmonary artery occlusion. Fetal cardiac function and haemodynamics were assessed by pulsed and tissue Doppler at baseline, 15 and 60 min after occlusion of the main pulmonary artery and 15 min after occlusion was released. Fetal ascending aorta and central venous pressures and blood gas values were monitored. Main pulmonary artery occlusion initially increased fetal heart rate (P <0.05) from [mean (SD)] 158 (7) to 188 (23) beats min(-1) and LV cardiac output (P <0.0001) from 629 (198) to 776 (283) ml min(-1). Combined cardiac output fell (P <0.0001) from 1524 (341) to 720 (273) ml min(-1). During main pulmonary artery occlusion, FO volume blood flow increased (P <0.001) from 507 (181) to 776 (283) ml min(-1). This increase was related to fetal tachycardia, because LV stroke volume did not change. Fetal ascending aortic blood pressure remained stable. Central venous pressure was higher (P <0.05) during the occlusion than after it was released. During the occlusion, fetal pH decreased and PCO2 increased. Left ventricular systolic dysfunction developed while LV diastolic function was preserved. Right ventricular systolic and diastolic function deteriorated after the occlusion. In conclusion, the FO has a limited capacity to increase its volume blood flow at near-term gestation.
Subject: blood flow
1184 Genetics, developmental biology, physiology
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion

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