Elevation of tumor necrosis factor alpha levels is associated with restless legs symptoms in clinically depressed patients

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Auvinen , P , Mäntyselkä , P , Koponen , H , Kautiainen , H , Korniloff , K , Ahonen , T & Vanhala , M 2018 , ' Elevation of tumor necrosis factor alpha levels is associated with restless legs symptoms in clinically depressed patients ' , Journal of Psychosomatic Research , vol. 115 . https://doi.org/10.1016/j.jpsychores.2018.09.008

Title: Elevation of tumor necrosis factor alpha levels is associated with restless legs symptoms in clinically depressed patients
Author: Auvinen, Piritta; Mäntyselkä, Pekka; Koponen, Hannu; Kautiainen, Hannu; Korniloff, Katariina; Ahonen, Tiina; Vanhala, Mauno
Other contributor: University of Helsinki, Department of Psychiatry
University of Helsinki, Kuopio University Hospital (KYS)


Date: 2018-12
Language: eng
Number of pages: 5
Belongs to series: Journal of Psychosomatic Research
ISSN: 0022-3999
DOI: https://doi.org/10.1016/j.jpsychores.2018.09.008
URI: http://hdl.handle.net/10138/308860
Abstract: Background: Restless legs syndrome is a sensorimotor disorder associated with several mental illnesses particularly depression. Methods: A cross-sectional study of primary care patients. The prevalence of restless legs symptoms was studied in 706 patients with depressive symptoms and 426 controls without a psychiatric diagnosis by using a structured questionnaire. The depressive symptoms were evaluated with the BDI and the psychiatric diagnosis was confirmed by means of a diagnostic interview (M.I.N.I.). The subjects with elevated depressive symptoms were divided into two groups subjects with depressive symptoms with and without clinical depression. Results: The prevalence of restless legs symptoms was 24.8% in the controls, 50.0% in the patients with clinical depression and 42.4% in the patients with depressive symptoms. CRP value was significantly higher (p =.003) in the clinically depressed patients than in the other groups. There was a higher concentration of TNF-alpha in the subjects with restless legs symptoms (7.4 ng/l +/- 3.2) compared with the subjects without symptoms (6.7 ng/1 +/- 2.3)(p Conclusions: TNF-alpha level was associated with restless legs symptoms only among subjects with depressive symptoms whether they had clinical depression or not. We suggest that TNF-alpha could be an underlying factor between restless legs symptoms and comorbidities.
Subject: Restless legs syndrome
TNF-alpha
Depressive disorder
Depression
Primary health care
C-REACTIVE PROTEIN
TNF-ALPHA
CYTOKINE LEVELS
METAANALYSIS
PREVALENCE
IRON
DISORDER
SLEEP
3124 Neurology and psychiatry
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