Ultrasonic Processing Technique as a Green Preparation Approach for Diacerein-Loaded Niosomes

Show full item record



Permalink

http://hdl.handle.net/10138/309041

Citation

Khan , M I , Madni , A , Hirvonen , J & Peltonen , L 2017 , ' Ultrasonic Processing Technique as a Green Preparation Approach for Diacerein-Loaded Niosomes ' , AAPS PharmSciTech , vol. 18 , no. 5 , pp. 1554-1563 . https://doi.org/10.1208/s12249-016-0622-z

Title: Ultrasonic Processing Technique as a Green Preparation Approach for Diacerein-Loaded Niosomes
Author: Khan, Muhammad Imran; Madni, Asadullah; Hirvonen, Jouni; Peltonen, Leena
Other contributor: University of Helsinki, University of Helsinki
University of Helsinki, University of Helsinki





Date: 2017-07
Language: eng
Number of pages: 10
Belongs to series: AAPS PharmSciTech
ISSN: 1530-9932
DOI: https://doi.org/10.1208/s12249-016-0622-z
URI: http://hdl.handle.net/10138/309041
Abstract: In this study, the feasibility of ultrasonic processing (UP) technique as green preparation method for production of poorly soluble model drug substance, diacerein, loaded niosomes was demonstrated. Also, the effects of different surfactant systems on niosomes' characteristics were analyzed. Niosomes were prepared using both the green UP technique and traditional thin-film hydration (TFH) technique, which requires the use of environmentally hazardous organic solvents. The studied surfactant systems were Span 20, Pluronic L64, and their mixture (Span 20 and Pluronic L64). Both the production techniques produced well-defined spherical vesicles, but the UP technique produced smaller and more monodisperse niosomes than TFH. The entrapment efficiencies with the UP method were lower than with TFH, but still at a feasible level. All the niosomal formulations released diacerein faster than pure drug, and the drug release rates from the niosomes produced by the UP method were higher than those from the TFH-produced niosomes. With UP technique, the optimum process conditions for small niosomal products with low PDI values and high entrapment efficiencies were obtained when 70% amplitude and 45-min sonication time were used. The overall results demonstrated the potency of UP technique as an alternative fast, cost-effective, and green preparation approach for production of niosomes, which can be utilized as drug carrier systems for poorly soluble drug materials.
Subject: diacerein
mixed surfactant system
niosomes
thin-film hydration
ultrasonic processing technique
IN-VITRO EVALUATION
DRUG-DELIVERY
PHYSICOCHEMICAL PROPERTIES
VESICLES NIOSOMES
CANDESARTAN CILEXETIL
LIPID NANOPARTICLES
TYLOXAPOL NIOSOMES
SUSTAINED-RELEASE
FORMULATION
CHOLESTEROL
317 Pharmacy
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
CorrectedProofs.pdf 368.5Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record