MIM-Deficient Mice Exhibit Anatomical Changes in Dendritic Spines, Cortex Volume and Brain Ventricles, and Functional Changes in Motor Coordination and Learning

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Minkeviciene , R , Hlushchenko , I , Virenque , A , Lahti , L , Khanal , P , Rauramaa , T , Koistinen , A , Leinonen , V , Noé , F M & Hotulainen , P 2019 , ' MIM-Deficient Mice Exhibit Anatomical Changes in Dendritic Spines, Cortex Volume and Brain Ventricles, and Functional Changes in Motor Coordination and Learning ' , Frontiers in Molecular Neuroscience , vol. 12 , 276 . https://doi.org/10.3389/fnmol.2019.00276

Title: MIM-Deficient Mice Exhibit Anatomical Changes in Dendritic Spines, Cortex Volume and Brain Ventricles, and Functional Changes in Motor Coordination and Learning
Author: Minkeviciene, Rimante; Hlushchenko, Iryna; Virenque, Anaïs; Lahti, Lauri; Khanal, Pushpa; Rauramaa, Tuomas; Koistinen, Arto; Leinonen, Ville; Noé, Francesco Mattia; Hotulainen, Pirta
Contributor: University of Helsinki, Medicum
University of Helsinki, Minerva Foundation Institute for Medical Research
University of Helsinki, Neuroscience Center
University of Helsinki, Neuroscience Center
University of Helsinki, Neuroscience Center
University of Helsinki, Medicum
Date: 2019-11-15
Language: eng
Number of pages: 20
Belongs to series: Frontiers in Molecular Neuroscience
ISSN: 1662-5099
URI: http://hdl.handle.net/10138/309075
Abstract: In this study, we performed a comprehensive behavioral and anatomical analysis of the Missing in Metastasis (Mtss1/MIM) knockout (KO) mouse brain. We also analyzed the expression of MIM in different brain regions at different ages. MIM is an I-BAR containing membrane curving protein, shown to be involved in dendritic spine initiation and dendritic branching in Purkinje cells in the cerebellum. Behavioral analysis of MIM KO mice revealed defects in both learning and reverse-learning, alterations in anxiety levels and reduced dominant behavior, and confirmed the previously described deficiency in motor coordination and pre-pulse inhibition. Anatomically, we observed enlarged brain ventricles and decreased cortical volume. Although MIM expression was relatively low in hippocampus after early development, hippocampal pyramidal neurons exhibited reduced density of thin and stubby dendritic spines. Learning deficiencies can be connected to all detected anatomical changes. Both behavioral and anatomical findings are typical for schizophrenia mouse models.
Subject: CORTICAL PYRAMIDAL NEURONS
DENSITY
MEMORY
PLATFORM
SCHIZOPHRENIA
anxiety
brain ventricles
dendritic spines
learning
motor coordination
3112 Neurosciences
3124 Neurology and psychiatry
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