Planar Chiral [2.2]Paracyclophane-Based Bisoxazoline Ligands and Their Applications in Cu-Mediated N-H Insertion Reaction

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http://hdl.handle.net/10138/309137

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Knoll , D M , Hu , Y , Hassan , Z , Nieger , M & Bräse , S 2019 , ' Planar Chiral [2.2]Paracyclophane-Based Bisoxazoline Ligands and Their Applications in Cu-Mediated N-H Insertion Reaction ' , Molecules , vol. 24 , no. 22 . https://doi.org/10.3390/molecules24224122

Title: Planar Chiral [2.2]Paracyclophane-Based Bisoxazoline Ligands and Their Applications in Cu-Mediated N-H Insertion Reaction
Author: Knoll, Daniel M.; Hu, Yuling; Hassan, Zahid; Nieger, Martin; Bräse, Stefan
Contributor: University of Helsinki, Department of Chemistry
Date: 2019-11
Language: eng
Number of pages: 14
Belongs to series: Molecules
ISSN: 1420-3049
URI: http://hdl.handle.net/10138/309137
Abstract: New catalysts for important C-N bond formation are highly sought after. In this work, we demonstrate the synthesis and viability of a new class of planar chiral [2.2]paracyclophane-based bisoxazoline (BOX) ligands for the copper-catalyzed N-H insertion of alpha -diazocarbonyls into anilines. The reaction features a wide substrate scope and moderate to excellent yields, and delivers the valuable products at ambient conditions.
Subject: [2
2]paracyclophane ligands
N-H insertion
alpha-diazocarbonyls
planar chirality
copper catalysis
ASYMMETRIC CONJUGATE ADDITION
ENANTIOSELECTIVE INSERTION
BONDS
CATALYSTS
DESIGN
IMINES
116 Chemical sciences
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