Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria

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dc.contributor.author Shishido, Tania Keiko
dc.contributor.author Popin, Rafael Vicentini
dc.contributor.author Jokela, Jouni
dc.contributor.author Wahlsten, Matti
dc.contributor.author Fiore, Marli Fatima
dc.contributor.author Fewer, David P.
dc.contributor.author Herfindal, Lars
dc.contributor.author Sivonen, Kaarina
dc.date.accessioned 2020-01-10T09:01:57Z
dc.date.available 2020-01-10T09:01:57Z
dc.date.issued 2019-12-24
dc.identifier.citation Shishido, T.K.; Popin, R.V.; Jokela, J.; Wahlsten, M.; Fiore, M.F.; Fewer, D.P.; Herfindal, L.; Sivonen, K. Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria. Toxins 2019, 12, 12.
dc.identifier.uri http://hdl.handle.net/10138/309207
dc.description.abstract Cyanobacteria are photosynthetic organisms that produce a large diversity of natural products with interesting bioactivities for biotechnological and pharmaceutical applications. Cyanobacterial extracts exhibit toxicity towards other microorganisms and cancer cells and, therefore, represent a source of potentially novel natural products for drug discovery. We tested 62 cyanobacterial strains isolated from various Brazilian biomes for antileukemic and antimicrobial activities. Extracts from 39 strains induced selective apoptosis in acute myeloid leukemia (AML) cancer cell lines. Five of these extracts also exhibited antifungal and antibacterial activities. Chemical and dereplication analyses revealed the production of nine known natural products. Natural products possibly responsible for the observed bioactivities and five unknown, chemically related chlorinated compounds present only in Brazilian cyanobacteria were illustrated in a molecular network. Our results provide new information on the vast biosynthetic potential of cyanobacteria isolated from Brazilian environments.
dc.publisher Multidisciplinary Digital Publishing Institute
dc.title Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria
dc.date.updated 2020-01-10T09:01:57Z
dc.type.uri http://purl.org/eprint/entityType/JournalArticle
dc.type.uri http://purl.org/eprint/entityType/Expression
dc.type.uri http://purl.org/eprint/entityType/Expression

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