Artificially Cloaked Viral Nanovaccine for Cancer Immunotherapy

Show simple item record Fusciello, Manlio Fontana, Flavia Tähtinen, Siri Capasso, Cristian Feola, Sara da Silva Lopes Martins, Beatriz Chiaro, Jacopo Peltonen, Karita Ylösmäki, Leena Ylösmäki, Erkko Hamdan Hissaoui, Firas Kari, Otto K. Ndika, Joseph Alenius, Harri Urtti, Arto Hirvonen, Jouni T. Santos, Hélder A. Cerullo, Vincenzo 2020-01-10T09:33:01Z 2020-01-10T09:33:01Z 2019-12-17
dc.identifier.citation Fusciello , M , Fontana , F , Tähtinen , S , Capasso , C , Feola , S , da Silva Lopes Martins , B , Chiaro , J , Peltonen , K , Ylösmäki , L , Ylösmäki , E , Hamdan Hissaoui , F , Kari , O K , Ndika , J , Alenius , H , Urtti , A , Hirvonen , J T , Santos , H A & Cerullo , V 2019 , ' Artificially Cloaked Viral Nanovaccine for Cancer Immunotherapy ' , Nature Communications , vol. 10 , 5747 .
dc.identifier.other PURE: 128160918
dc.identifier.other PURE UUID: a47d9356-04ba-48d3-bc82-680520378026
dc.identifier.other WOS: 000503009300004
dc.identifier.other ORCID: /0000-0002-5029-1657/work/67132320
dc.identifier.other ORCID: /0000-0002-3063-451X/work/67132405
dc.identifier.other ORCID: /0000-0002-1201-5010/work/67133244
dc.identifier.other ORCID: /0000-0001-9112-6917/work/67134477
dc.identifier.other ORCID: /0000-0003-0669-1300/work/67135463
dc.identifier.other ORCID: /0000-0001-7850-6309/work/103469167
dc.description.abstract Virus-based cancer vaccines are nowadays considered an interesting approach in the field of cancer immunotherapy, despite the observation that the majority of the immune responses they elicit are against the virus and not against the tumor. In contrast, targeting tumor associated antigens is effective, however the identification of these antigens remains challenging. Here, we describe ExtraCRAd, a multi-vaccination strategy focused on an oncolytic virus artificially wrapped with tumor cancer membranes carrying tumor antigens. We demonstrate that ExtraCRAd displays increased infectivity and oncolytic effect in vitro and in vivo. We show that this nanoparticle platform controls the growth of aggressive melanoma and lung tumors in vivo both in preventive and therapeutic setting, creating a highly specific anti-cancer immune response. In conclusion, ExtraCRAd might serve as the next generation of personalized cancer vaccines with enhanced features over standard vaccination regimens, representing an alternative way to target cancer. en
dc.format.extent 13
dc.language.iso eng
dc.relation.ispartof Nature Communications
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject ADENOVIRUS
dc.subject ANTIGEN
dc.subject CO-DELIVERY
dc.subject GENE-TRANSFER
dc.subject IN-VIVO
dc.subject SOLID TUMORS
dc.subject T-CELL THERAPY
dc.subject VACCINATION
dc.subject immunotherapy
dc.subject biohybrid nanoparticles
dc.subject oncolytic vaccines
dc.subject oncolytic virus
dc.subject oncoimmunology
dc.subject 317 Pharmacy
dc.subject 318 Medical biotechnology
dc.title Artificially Cloaked Viral Nanovaccine for Cancer Immunotherapy en
dc.type Article
dc.contributor.organization ImmunoViroTherapy Lab
dc.contributor.organization Division of Pharmaceutical Biosciences
dc.contributor.organization Drug Research Program
dc.contributor.organization Digital Precision Cancer Medicine (iCAN)
dc.contributor.organization Nanomedicines and Biomedical Engineering
dc.contributor.organization Division of Pharmaceutical Chemistry and Technology
dc.contributor.organization Drug Delivery Unit
dc.contributor.organization Department of Bacteriology and Immunology
dc.contributor.organization Medicum
dc.contributor.organization HUMI - Human Microbiome Research
dc.contributor.organization Drug Delivery
dc.contributor.organization Jouni Hirvonen / Principal Investigator
dc.contributor.organization Helsinki One Health (HOH)
dc.contributor.organization Helsinki Institute of Life Science HiLIFE
dc.description.reviewstatus Peer reviewed
dc.relation.issn 2041-1723
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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