Atomic layer deposition-A novel method for the ultrathin coating of minitablets

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Hautala , J , Kääriäinen , T , Hoppu , P , Kemell , M , Heinämäki , J , Cameron , D , George , S & Juppo , A M 2017 , ' Atomic layer deposition-A novel method for the ultrathin coating of minitablets ' , International Journal of Pharmaceutics , vol. 531 , no. 1 , pp. 47-58 .

Title: Atomic layer deposition-A novel method for the ultrathin coating of minitablets
Author: Hautala, Jaana; Kääriäinen, Tommi; Hoppu, Pekka; Kemell, Marianna; Heinämäki, Jyrki; Cameron, David; George, Steven; Juppo, Anne Mari
Contributor organization: Faculty of Pharmacy
University of Helsinki
Formulation and industrial pharmacy
Department of Chemistry
Faculty of Science
Anne Juppo / Principal Investigator
Division of Pharmaceutical Chemistry and Technology
Pharmaceutical Design and Discovery group
Drug Research Program
Date: 2017-10-05
Language: eng
Number of pages: 12
Belongs to series: International Journal of Pharmaceutics
ISSN: 0378-5173
Abstract: We introduce atomic layer deposition (ALD) as a novel method for the ultrathin coating (nanolayering) of minitablets. The effects of ALD coating on the tablet characteristics and taste masking were investigated and compared with the established coating method. Minitablets containing bitter tasting denatonium benzoate were coated by ALD using three different TiO2 nanolayer thicknesses (number of deposition cycles). The established coating of minitablets was performed in a laboratory-scale fluidized-bed apparatus using four concentration levels of aqueous Eudragit (R) E coating polymer. The coated minitablets were studied with respect to the surface morphology, taste masking capacity, in vitro disintegration and dissolution, mechanical properties, and uniformity of content. The ALD thin coating resulted in minimal increase in the dimensions and weight of minitablets in comparison to original tablet cores. Surprisingly, ALD coating with TiO2 nanolayers decreased the mechanical strength, and accelerated the in vitro disintegration of minitablets. Unlike previous studies, the studied levels of TiO2 nanolayers on tablets were also inadequate for effective taste masking. In summary, ALD permits a simple and rapid method for the ultrathin coating (nanolayering) of minitablets, and provides nanoscale-range TiO2 coatings on porous minitablets. More research, however, is needed to clarify its potential in tablet taste masking applications. (C) 2017 Elsevier B.V. All rights reserved.
Subject: Atomic layer deposition
Thin film coating
Taste masking
Polymer film coating
317 Pharmacy
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion

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