Synthesis of spiro[indoline-3,4'-pyrano[3,2-c]quinolone]-3'-carbonitriles

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Aly , A A , El-Sheref , E M , Mourad , A-F E , Brown , A B , Bräse , S , Bakheet , M E M & Nieger , M 2018 , ' Synthesis of spiro[indoline-3,4'-pyrano[3,2-c]quinolone]-3'-carbonitriles ' , Monatshefte für Chemie , vol. 149 , no. 3 , pp. 635-644 . https://doi.org/10.1007/s00706-017-2078-6

Title: Synthesis of spiro[indoline-3,4'-pyrano[3,2-c]quinolone]-3'-carbonitriles
Author: Aly, Ashraf A.; El-Sheref, Essmat M.; Mourad, Aboul-Fetouh E.; Brown, Alan B.; Bräse, Stefan; Bakheet, Momtaz E. M.; Nieger, Martin
Contributor: University of Helsinki, Department of Chemistry
Date: 2018-03
Language: eng
Number of pages: 10
Belongs to series: Monatshefte für Chemie
ISSN: 0026-9247
URI: http://hdl.handle.net/10138/309240
Abstract: Quinoline-2,4-diones reacted with 2-(2-oxo-1,2-dihydroindol-3-ylidene)malononitrile in pyridine to give 2'-amino-2,5'-dioxo-5',6'-dihydrospiro(indoline-3,4'-pyrano[3,2-c]quinoline)-3'-carbonitriles in good to excellent yields. The structures of all new products were proven using one- and two-dimensional NMR, IR, and mass spectral data, and in five cases X-ray structural analyses. The possible mechanism for the reaction is also discussed. [GRAPHICS] .
Subject: Quinolin-2,4-diones
Isatinemalononitrile
Spiro-compounds
X-ray analysis
IN-VITRO
DERIVATIVES
SPIROOXINDOLES
INHIBITORS
ANTIBIOTICS
EFFICIENT
ANALOGS
116 Chemical sciences
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