Mean muscle attenuation correlates with severe acute pancreatitis unlike visceral adipose tissue and subcutaneous adipose tissue

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http://hdl.handle.net/10138/309261

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Sternby , H , Mahle , M , Linder , N , Erichson-Kirst , L , Verdonk , R C , Dimova , A , Ignatavicius , P , Ilzarbe , L , Koiva , P , Penttilä , A , Regner , S , Bollen , T L , Brill , R , Stangl , F , Wohlgemuth , W A , Singh , V , Busse , H , Michl , P , Beer , S & Rosendahl , J 2019 , ' Mean muscle attenuation correlates with severe acute pancreatitis unlike visceral adipose tissue and subcutaneous adipose tissue ' , United european gastroenterology journal , vol. 7 , no. 10 , pp. 1312–1320 . https://doi.org/10.1177/2050640619882520

Title: Mean muscle attenuation correlates with severe acute pancreatitis unlike visceral adipose tissue and subcutaneous adipose tissue
Author: Sternby, Hanna; Mahle, Mariella; Linder, Nicolas; Erichson-Kirst, Laureen; Verdonk, Robert C.; Dimova, Alexandra; Ignatavicius, Povilas; Ilzarbe, Lucas; Koiva, Peeter; Penttilä, Anne; Regner, Sara; Bollen, Thomas L.; Brill, Richard; Stangl, Franz; Wohlgemuth, Walter A.; Singh, Vijay; Busse, Harald; Michl, Patrick; Beer, Sebastian; Rosendahl, Jonas
Contributor: University of Helsinki, Clinicum
Date: 2019-12
Language: eng
Number of pages: 9
Belongs to series: United european gastroenterology journal
ISSN: 2050-6406
URI: http://hdl.handle.net/10138/309261
Abstract: Background: Acute pancreatitis (AP) is a frequent disorder with considerable morbidity and mortality. Obesity has previously been reported to influence disease severity. Objective The aim of this study was to investigate the association of adipose and muscle parameters with the severity grade of AP. Methods: In total 454 patients were recruited. The first contrast-enhanced computed tomography of each patient was reviewed for adipose and muscle tissue parameters at L3 level. Associations with disease severity were analysed through logistic regression analysis. The predictive capacity of the parameters was investigated using receiver operating characteristic (ROC) curves. Results: No distinct variation was found between the AP severity groups in either adipose tissue parameters (visceral adipose tissue and subcutaneous adipose tissue) or visceral muscle ratio. However, muscle mass and mean muscle attenuation differed significantly with p-values of 0.037 and 0.003 respectively. In multivariate analysis, low muscle attenuation was associated with severe AP with an odds ratio of 4.09 (95% confidence intervals: 1.61-10.36, p-value 0.003). No body parameter presented sufficient predictive capability in ROC-curve analysis. Conclusions: Our results demonstrate that a low muscle attenuation level is associated with an increased risk of severe AP. Future prospective studies will help identify the underlying mechanisms and characterise the influence of body composition parameters on AP.
Subject: Acute pancreatitis
severity
visceral adipose tissue
mean muscle attenuation
muscle mass
BODY-MASS INDEX
COMPUTED-TOMOGRAPHY
SKELETAL-MUSCLE
OBESITY
FAT
PREDICTION
MORTALITY
RISK
NECROSIS
3121 Internal medicine
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