Ventilation/Perfusion SPECT Imaging-Diagnosing Other Cardiopulmonary Diseases Beyond Pulmonary Embolism

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http://hdl.handle.net/10138/309284

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Bajc , M & Lindqvist , A 2019 , ' Ventilation/Perfusion SPECT Imaging-Diagnosing Other Cardiopulmonary Diseases Beyond Pulmonary Embolism ' , Seminars in Nuclear Medicine , vol. 49 , no. 1 , pp. 4-10 . https://doi.org/10.1053/j.semnuclmed.2018.10.012

Title: Ventilation/Perfusion SPECT Imaging-Diagnosing Other Cardiopulmonary Diseases Beyond Pulmonary Embolism
Author: Bajc, Marika; Lindqvist, Ari
Contributor: University of Helsinki, Keuhkosairauksien yksikkö
Date: 2019-01
Language: eng
Number of pages: 7
Belongs to series: Seminars in Nuclear Medicine
ISSN: 0001-2998
URI: http://hdl.handle.net/10138/309284
Abstract: Ventilation/perfusion single-photon emission computed tomography (V/P SPECT) is the scintigraphic technique recommended primarily for the diagnosis of acute pulmonary embolism (PE) and is golden standard for the diagnosis of chronic PE. Furthermore, interpreting ventilation and corresponding perfusion images enables pattern recognition of many other cardiopulmonary disorders that affect lung function and also allows quantification of their extent. Using Technegas for the ventilation imaging, grading of small airway disease in COPD is possible and the method is recommended for PE diagnosis in patients with severe COPD that is not possible with radiolabelled liquid aerosols. An optimal combination of nuclide activities, acquisition times for ventilation and perfusion, collimators, and imaging matrix yields an adequate V/P SPECT study in approximately 20 minutes of imaging time. The holistic interpretation strategy of V/P SPECT uses all relevant information about the patient and ventilation/ perfusion patterns. PE is diagnosed when there is more than one subsegment showing a V/P mismatch representing an anatomic lung unit. Apart from PE, other pathologies should be identified and reported, such as obstructive lung disease, heart failure, and pneumonia according to the European Association of Nuclear Medicine guidelines. Semin Nucl Med 49:4-10 (C) 2018 Published by Elsevier Inc.
Subject: PERFUSION SCINTIGRAPHY
LUNG-FUNCTION
HYPERTENSION
COPD
THROMBOEMBOLISM
ANGIOGRAPHY
DEFECTS
3126 Surgery, anesthesiology, intensive care, radiology
3121 General medicine, internal medicine and other clinical medicine
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