Regulation of the complement system and immunological tolerance in pregnancy

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http://hdl.handle.net/10138/309544

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Teirilä , L , Heikkinen-Eloranta , J , Kotimaa , J , Meri , S & Lokki , A I 2019 , ' Regulation of the complement system and immunological tolerance in pregnancy ' , Seminars in immunology , vol. 45 , 101337 . https://doi.org/10.1016/j.smim.2019.101337

Title: Regulation of the complement system and immunological tolerance in pregnancy
Author: Teirilä, Laura; Heikkinen-Eloranta, Jenni; Kotimaa, Juha; Meri, Seppo; Lokki, A. Inkeri
Contributor: University of Helsinki, HUSLAB
University of Helsinki, Pregnancy and Genes
University of Helsinki, Department of Bacteriology and Immunology
University of Helsinki, HUSLAB
University of Helsinki, Department of Bacteriology and Immunology
Date: 2019-10
Language: eng
Number of pages: 11
Belongs to series: Seminars in immunology
ISSN: 1044-5323
URI: http://hdl.handle.net/10138/309544
Abstract: Preeclampsia is a serious vascular complication of the human pregnancy, whose etiology is still poorly understood. In preeclampsia, exacerbated apoptosis and fragmentation of the placental tissue occurs due to developmental qualities of the placental trophoblast cells and/or mechanical and oxidative distress to the syncytiotrophoblast, which lines the placental villi. Dysregulation of the complement system is recognized as one of the mechanisms of the disease pathology. Complement has the ability to promote inflammation and facilitate phagocytosis of placenta-derived particles and apoptotic cells by macrophages. In preeclampsia, an overload of placental cell damage or dysregulated complement system may lead to insufficient clearance of apoptotic particles and placenta-derived debris. Excess placental damage may lead to sequestration of microparticles, such as placental vesicles, to capillaries in the glomeruli of the kidney and other vulnerable tissues. This phenomenon could contribute to the manifestations of typical diagnostic symptoms of preeclampsia: proteinuria and new-onset hypertension. In this review we propose that the complement system may serve as a regulator of the complex tolerance and clearance processes that are fundamental in healthy pregnancy. It is therefore recommended that further research be conducted to elucidate the interactions between components of the complement system and immune responses in the context of complicated and healthy pregnancy.
Subject: Pregnancy
Complement
Preeclampsia
Inflammation
Apoptosis
Tolerance
MEMBRANE ATTACK COMPLEX
PRIMARY HUMAN MONOCYTES
NATURAL-KILLER-CELLS
FETAL DNA
TROPHOBLAST DEPORTATION
C4B-BINDING PROTEIN
PATHWAY ACTIVATION
BETA(2) INTEGRINS
APOPTOTIC CELLS
MATERNAL PLASMA
3111 Biomedicine
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