Circulating metabolites and the risk of type 2 diabetes : a prospective study of 11,896 young adults from four Finnish cohorts

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Ahola-Olli , A V , Mustelin , L , Kalimeri , M , Kettunen , J , Jokelainen , J , Auvinen , J , Puukka , K , Havulinna , A S , Lehtimäki , T , Kähönen , M , Juonala , M , Keinänen-Kiukaanniemi , S , Salomaa , V , Perola , M , Järvelin , M-R , Ala-Korpela , M , Raitakari , O & Wurtz , P 2019 , ' Circulating metabolites and the risk of type 2 diabetes : a prospective study of 11,896 young adults from four Finnish cohorts ' , Diabetologia , vol. 62 , no. 12 , pp. 2298-2309 . https://doi.org/10.1007/s00125-019-05001-w

Title: Circulating metabolites and the risk of type 2 diabetes : a prospective study of 11,896 young adults from four Finnish cohorts
Author: Ahola-Olli, Ari V.; Mustelin, Linda; Kalimeri, Maria; Kettunen, Johannes; Jokelainen, Jari; Auvinen, Juha; Puukka, Katri; Havulinna, Aki S.; Lehtimäki, Terho; Kähönen, Mika; Juonala, Markus; Keinänen-Kiukaanniemi, Sirkka; Salomaa, Veikko; Perola, Markus; Järvelin, Marjo-Riitta; Ala-Korpela, Mika; Raitakari, Olli; Wurtz, Peter
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Clinicum
University of Helsinki, Staff Services
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, University Management
Date: 2019-12
Language: eng
Number of pages: 12
Belongs to series: Diabetologia
ISSN: 0012-186X
URI: http://hdl.handle.net/10138/309648
Abstract: Aims/hypothesis Metabolomics technologies have identified numerous blood biomarkers for type 2 diabetes risk in case-control studies of middle-aged and older individuals. We aimed to validate existing and identify novel metabolic biomarkers predictive of future diabetes in large cohorts of young adults. Methods NMR metabolomics was used to quantify 229 circulating metabolic measures in 11,896 individuals from four Finnish observational cohorts (baseline age 24-45 years). Associations between baseline metabolites and risk of developing diabetes during 8-15 years of follow-up (392 incident cases) were adjusted for sex, age, BMI and fasting glucose. Prospective metabolite associations were also tested with fasting glucose, 2 h glucose and HOMA-IR at follow-up. Results Out of 229 metabolic measures, 113 were associated with incident type 2 diabetes in meta-analysis of the four cohorts (ORs per 1 SD: 0.59-1.50; p Conclusions/interpretation Metabolic biomarkers across multiple molecular pathways are already predictive of the long-term risk of diabetes in young adults. Comprehensive metabolic profiling may help to target preventive interventions for young asymptomatic individuals at increased risk.
Subject: Branched-chain amino acid
Isoleucine
Leucine
Metabolomics
Type 2 diabetes
NUCLEAR-MAGNETIC-RESONANCE
CHAIN AMINO-ACIDS
IMPAIRED FASTING GLUCOSE
INSULIN-RESISTANCE
POOLED ANALYSIS
LIFE-STYLE
FOLLOW-UP
METABOLOMICS
BIOMARKERS
LIPOPROTEIN
3121 Internal medicine
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