Circulating metabolites in progression to islet autoimmunity and type 1 diabetes

Show full item record



Permalink

http://hdl.handle.net/10138/309793

Citation

Lamichhane , S , Kemppainen , E , Trost , K , Siljander , H , Hyöty , H , Ilonen , J , Toppari , J , Veijola , R , Hyötyläinen , T , Knip , M & Oresic , M 2019 , ' Circulating metabolites in progression to islet autoimmunity and type 1 diabetes ' , Diabetologia , vol. 62 , no. 12 , pp. 2287-2297 . https://doi.org/10.1007/s00125-019-04980-0

Title: Circulating metabolites in progression to islet autoimmunity and type 1 diabetes
Author: Lamichhane, Santosh; Kemppainen, Esko; Trost, Kajetan; Siljander, Heli; Hyöty, Heikki; Ilonen, Jorma; Toppari, Jorma; Veijola, Riitta; Hyötyläinen, Tuulia; Knip, Mikael; Oresic, Matej
Contributor: University of Helsinki, Clinicum
University of Helsinki, HUS Children and Adolescents
Date: 2019-12
Language: eng
Number of pages: 11
Belongs to series: Diabetologia
ISSN: 0012-186X
URI: http://hdl.handle.net/10138/309793
Abstract: Aims/hypothesis Metabolic dysregulation may precede the onset of type 1 diabetes. However, these metabolic disturbances and their specific role in disease initiation remain poorly understood. In this study, we examined whether children who progress to type 1 diabetes have a circulatory polar metabolite profile distinct from that of children who later progress to islet autoimmunity but not type 1 diabetes and a matched control group. Methods We analysed polar metabolites from 415 longitudinal plasma samples in a prospective cohort of children in three study groups: those who progressed to type 1 diabetes; those who seroconverted to one islet autoantibody but not to type 1 diabetes; and an antibody-negative control group. Metabolites were measured using two-dimensional GC high-speed time of flight MS. Results In early infancy, progression to type 1 diabetes was associated with downregulated amino acids, sugar derivatives and fatty acids, including catabolites of microbial origin, compared with the control group. Methionine remained persistently upregulated in those progressing to type 1 diabetes compared with the control group and those who seroconverted to one islet autoantibody. The appearance of islet autoantibodies was associated with decreased glutamic and aspartic acids. Conclusions/interpretation Our findings suggest that children who progress to type 1 diabetes have a unique metabolic profile, which is, however, altered with the appearance of islet autoantibodies. Our findings may assist with early prediction of the disease.
Subject: Beta cell autoimmunity
Metabolomics
Type 1 diabetes
AMINO-ACID-METABOLISM
BISPHENOL-A
RISK
MICROBIOME
CHILDREN
DISCOVERY
EXPOSURE
HLA-DQB1
TOOL
3121 Internal medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Lamichhane2019_ ... ingMetabolitesInProgre.pdf 2.161Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record