Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging

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Soikkeli , M , Kettunen , M I , Nivajärvi , R , Olsson , V , Ronkko , S , Laakkonen , J P , Lehto , V-P , Kavakka , J & Heikkinen , S 2019 , ' Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging ' , Contrast Media & Molecular Imaging , vol. 2019 , 5629597 . https://doi.org/10.1155/2019/5629597

Title: Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging
Author: Soikkeli, Maiju; Kettunen, Mikko I.; Nivajärvi, Riikka; Olsson, Venla; Ronkko, Seppo; Laakkonen, Johanna P.; Lehto, Vesa-Pekka; Kavakka, Jari; Heikkinen, Sami
Contributor: University of Helsinki, Department of Chemistry
University of Helsinki, Department of Chemistry
University of Helsinki, Department of Chemistry
Date: 2019-12-24
Language: eng
Number of pages: 8
Belongs to series: Contrast Media & Molecular Imaging
ISSN: 1555-4309
URI: http://hdl.handle.net/10138/309986
Abstract: Magnetic resonance imaging examinations are frequently carried out using contrast agents to improve the image quality. Practically all clinically used contrast agents are based on paramagnetic metals and lack in selectivity and specificity. A group of stable organic radicals, nitroxides, has raised interest as new metal-free contrast agents for MRI. Their structures can easily be modified to incorporate different functionalities. In the present study, a stable nitroxide TEEPO (2,2,6,6-tetraethylpiperidin-1-oxyl) was linked to a glucose moiety (Glc) to construct a water-soluble, potentially tumor-targeting compound with contrast-enhancing ability. The ability was assessed with in vivo MRI experiments. The constructed TEEPO-Glc agent proved to shorten the T-1 relaxation time in tumor, while the T-1 time in healthy brain tissue remained the same. The results indicate the potential of TEEPO-Glc as a valuable addition to the growing field of metal-free contrast enhancement in MRI-based diagnostics.
Subject: MRI
GADOLINIUM
RADICALS
WATER
MECHANISMS
RELAXIVITY
POLYMERS
116 Chemical sciences
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