The Genetic Background of Metabolic Trait Clusters in Children and Adolescents

Show full item record



Permalink

http://hdl.handle.net/10138/310194

Citation

Silventoinen , K , Gouveia , E , Jelenkovic , A , Maia , J , Antunes , A M , Pinheiro de Carvalho , M A A , Brehm , A M , Thomis , M , Lefevre , J , Kaprio , J & Freitas , D 2017 , ' The Genetic Background of Metabolic Trait Clusters in Children and Adolescents ' , Metabolic Syndrome and Related Disorders , vol. 15 , no. 7 , pp. 329-336 . https://doi.org/10.1089/met.2017.0013

Title: The Genetic Background of Metabolic Trait Clusters in Children and Adolescents
Author: Silventoinen, Karri; Gouveia, Elvio; Jelenkovic, Aline; Maia, Jose; Antunes, Antonio M.; Pinheiro de Carvalho, Miguel A. A.; Brehm, Antonio M.; Thomis, Martine; Lefevre, Johan; Kaprio, Jaakko; Freitas, Duarte
Contributor organization: University of Helsinki
Department of Social Research (2010-2017)
Sociology
Center for Population, Health and Society
Clinicum
Institute for Molecular Medicine Finland
Department of Public Health
Helsinki Institute of Life Science HiLIFE
Population Research Unit (PRU)
Genetic Epidemiology
Date: 2017-09
Language: eng
Number of pages: 8
Belongs to series: Metabolic Syndrome and Related Disorders
ISSN: 1540-4196
DOI: https://doi.org/10.1089/met.2017.0013
URI: http://hdl.handle.net/10138/310194
Abstract: Background: It is well known that metabolic risk factors of cardiovascular diseases are correlated, but the background of this clustering in children is more poorly known than in adults. Thus, we studied the contribution of genetic and environmental factors to the clustering of metabolic traits in childhood and adolescence. Data and Methods: Nine metabolic traits were measured in 214 complete twin pairs aged 3-18 years in the Autonomous Region of Madeira, Portugal, in 2007 and 2008. The variation of and covariations between the traits were decomposed into genetic and environmental components by using classical genetic twin modeling. Results: A model, including additive genetic and environmental factors unique for each twin individual, explained the variation of metabolic factors well. Under this model, the heritability estimates varied from 0.47 (systolic blood pressure in children under 12 years of age) to 0.91 (high-density lipoprotein [HDL] cholesterol in adolescents 12 years of age or older). The most systematic correlations were found between adiposity (body mass index and waist circumference) and blood lipids (HDL cholesterol, low-density lipoprotein cholesterol, and triglycerides), as well as blood pressure. These correlations were mainly explained by common genetic factors. Conclusions: Our results suggest that obesity, in particular, is behind the clustering of metabolic factors in children and adolescents. Both general and abdominal obesity partly share the same genetic background as blood lipids and blood pressure. Obesity prevention early in childhood is important in reducing the risk of metabolic diseases in adulthood.
Subject: metabolic syndrome
genetics
twins
children
adolescents
BODY-MASS INDEX
ENVIRONMENTAL-INFLUENCES
CARDIOVASCULAR-DISEASE
PHYSICAL-ACTIVITY
RISK-FACTORS
TWIN
HERITABILITY
PHENOTYPES
ADULTHOOD
OBESITY
3121 General medicine, internal medicine and other clinical medicine
3111 Biomedicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
MetS_Portugal_1_.pdf 392.0Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record