Cytoskeletal proteins in the cell nucleus : a special nuclear actin perspective

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http://hdl.handle.net/10138/310226

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Percipallea , P & Vartiainen , M 2019 , ' Cytoskeletal proteins in the cell nucleus : a special nuclear actin perspective ' , Molecular Biology of the Cell , vol. 30 , no. 15 , pp. 1781-1785 . https://doi.org/10.1091/mbc.E18-10-0645

Title: Cytoskeletal proteins in the cell nucleus : a special nuclear actin perspective
Author: Percipallea, Piergiorgio; Vartiainen, Maria
Other contributor: University of Helsinki, Doctoral Programme in Integrative Life Science




Date: 2019-07-15
Language: eng
Number of pages: 5
Belongs to series: Molecular Biology of the Cell
ISSN: 1059-1524
DOI: https://doi.org/10.1091/mbc.E18-10-0645
URI: http://hdl.handle.net/10138/310226
Abstract: The emerging role of cytoskeletal proteins in the cell nucleus has become a new frontier in cell biology. Actin and actin-binding proteins regulate chromatin and gene expression, but importantly they are beginning to be essential players in genome organization. These actin-based functions contribute to genome stability and integrity while affecting DNA replication and global transcription patterns. This is likely to occur through interactions of actin with nuclear components including nuclear lamina and subnuclear organelles. An exciting future challenge is to understand how these actin-based genome-wide mechanisms may regulate development and differentiation by interfering with the mechanical properties of the cell nucleus and how regulated actin polymerization plays a role in maintaining nuclear architecture. With a special focus on actin, here we summarize how cytoskeletal proteins operate in the nucleus and how they may be important to consolidate nuclear architecture for sustained gene expression or silencing.
Subject: BETA-ACTIN
MESSENGER-RNA
F-ACTIN
HNRNP-U
TRANSCRIPTION
GENE
INITIATION
COMPLEX
1182 Biochemistry, cell and molecular biology
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