Bowel Biofilms : Tipping Points between a Healthy and Compromised Gut?

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Tytgat , H L P , Nobrega , F L , van der Oost , J & de Vos , W M 2019 , ' Bowel Biofilms : Tipping Points between a Healthy and Compromised Gut? ' , Trends in Microbiology , vol. 27 , no. 1 , pp. 17-25 . https://doi.org/10.1016/j.tim.2018.08.009

Title: Bowel Biofilms : Tipping Points between a Healthy and Compromised Gut?
Author: Tytgat, Hanne L. P.; Nobrega, Franklin L.; van der Oost, John; de Vos, Willem M.
Contributor: University of Helsinki, Department of Bacteriology and Immunology
Date: 2019-01
Language: eng
Number of pages: 9
Belongs to series: Trends in Microbiology
ISSN: 0966-842X
URI: http://hdl.handle.net/10138/310697
Abstract: Bacterial communities are known to impact human health and disease. Mixed species biofilms, mostly pathogenic in nature, have been observed in dental and gastric infections as well as in intestinal diseases, chronic gut wounds and colon cancer. Apart from the appendix, the presence of thick polymicrobial biofilms in the healthy gut mucosa is still debated. Polymicrobial biofilms containing potential pathogens appear to be an early-warning signal of developing disease and can be regarded as a tipping point between a healthy and a diseased state of the gut mucosa. Key biofilm-forming pathogens and associated molecules hold promise as biomarkers. Criteria to distinguish microcolonies from biofilms are crucial to provide clarity when reporting biofilm-related phenomena in health and disease in the gut.
Subject: MICROBIAL BIOFILMS
MUCOSAL FLORA
MUCUS LAYERS
COMMUNITIES
MUCIN
ORGANIZATION
METABOLISM
COLON
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
1183 Plant biology, microbiology, virology
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