Chronic norovirus infection in primary immune deficiency disorders : an international case series

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http://hdl.handle.net/10138/310699

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Rolfes , M C , Sriaroon , P , Saldana , B J D , Dvorak , C C , Chapdelaine , H , Ferdman , R M , Chen , K , Jolles , S , Patel , N C , Kim , Y J , Tarrant , T K , Martelius , T , Seppanen , M & Joshi , A Y 2019 , ' Chronic norovirus infection in primary immune deficiency disorders : an international case series ' , Diagnostic Microbiology and Infectious Disease , vol. 93 , no. 1 , pp. 69-73 . https://doi.org/10.1016/j.diagmicrobio.2018.08.002

Title: Chronic norovirus infection in primary immune deficiency disorders : an international case series
Author: Rolfes, M. C.; Sriaroon, P.; Saldana, B. J. Davila; Dvorak, C. C.; Chapdelaine, H.; Ferdman, R. M.; Chen, K.; Jolles, S.; Patel, N. C.; Kim, Y. J.; Tarrant, T. K.; Martelius, T.; Seppanen, M.; Joshi, A. Y.
Contributor: University of Helsinki, Infektiosairauksien yksikkö
University of Helsinki, Children's Hospital
Date: 2019-01
Language: eng
Number of pages: 5
Belongs to series: Diagnostic Microbiology and Infectious Disease
ISSN: 0732-8893
URI: http://hdl.handle.net/10138/310699
Abstract: Objective: Predictive factors associated with clinical outcomes of chronic norovirus infection (CNI) in primary immunodeficiency diseases (PIDD) are lacking. Method: We sought to characterize CNI using a multi-institutional cohort of patients with PIDD and CNI using the Clinical Immunology Society's CIS-PIDD Listserv e-mail group. Results: Thirty-four subjects (21 males and 13 females) were reported from centers across North America, Europe, and Asia. All subjects were receiving high doses (median IgG dose: 1200 mg/kg/month) of supplemental immunoglobulin therapy. Fifty-three percent had a complete absence of B cells (median B-cell count 0; range 0-139 cells/mu L). Common Variable Immune Deficiency (CVID) subjects manifested a unique phenotype with B-cell lymphopenia, non O+ blood type, and villous atrophy (logistic regression model, P = 0.01). Five subjects died, all of whom had no evidence of villous atrophy. Conclusion: While Norovirus (NoV) is thought to replicate in B cells, in this PIDD cohort of CNI, B-cell lymphopenia was common, indicating that the presence of B lymphocytes is not essential for CNI. (C) 2018 Published by Elsevier Inc.
Subject: Norovirus
Primary immunodeficiency diseases PIDD
CVID, SCID, transplant, immunocompromised
Chronic gastroenteritis
STEM-CELL TRANSPLANTATION
GASTROENTERITIS
RECIPIENTS
PREVALENCE
CHILDREN
IMPACT
3121 General medicine, internal medicine and other clinical medicine
3111 Biomedicine
1183 Plant biology, microbiology, virology
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