Lumen , D , Näkki , S , Imlimthan , S , Lambidis , E , Sarparanta , M , Xu , W , Lehto , V-P & Airaksinen , A J 2019 , ' Site-Specific In-111-Radiolabeling of Dual-PEGylated Porous Silicon Nanoparticles and Their In Vivo Evaluation in Murine 4T1 Breast Cancer Model ' , Pharmaceutics , vol. 11 , no. 12 , 686 . https://doi.org/10.3390/pharmaceutics11120686
Title: | Site-Specific In-111-Radiolabeling of Dual-PEGylated Porous Silicon Nanoparticles and Their In Vivo Evaluation in Murine 4T1 Breast Cancer Model |
Author: | Lumen, Dave; Näkki, Simo; Imlimthan, Surachet; Lambidis, Elisavet; Sarparanta, Mirkka; Xu, Wujun; Lehto, Vesa-Pekka; Airaksinen, Anu J. |
Contributor organization: | Department of Chemistry Tracers in Molecular Imaging (TRIM) Helsinki In Vivo Animal Imaging Platform (HAIP) |
Date: | 2019-12 |
Language: | eng |
Number of pages: | 16 |
Belongs to series: | Pharmaceutics |
ISSN: | 1999-4923 |
DOI: | https://doi.org/10.3390/pharmaceutics11120686 |
URI: | http://hdl.handle.net/10138/310739 |
Abstract: | Polyethylene glycol (PEG) has been successfully used for improving circulation time of several nanomaterials but prolonging the circulation of porous silicon nanoparticles (PSi NPs) has remained challenging. Here, we report a site specific radiolabeling of dual-PEGylated thermally oxidized porous silicon (DPEG-TOPSi) NPs and investigation of influence of the PEGylation on blood circulation time of TOPSi NPs. Trans-cyclooctene conjugated DPEG-TOPSi NPs were radiolabeled through a click reaction with [In-111]In-DOTA-PEG(4)-tetrazine (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and the particle behavior was evaluated in vivo in Balb/c mice bearing 4T1 murine breast cancer allografts. The dual-PEGylation significantly prolonged circulation of [In-111]In-DPEG-TOPSi particles when compared to non-PEGylated control particles, yielding 10.8 +/- 1.7% of the injected activity/g in blood at 15 min for [In-111]In-DPEG-TOPSi NPs. The improved circulation time will be beneficial for the accumulation of targeted DPEG-TOPSi to tumors. |
Subject: |
SPECT
indium-111 click chemistry porous silicon IEDDA DIELS-ALDER REACTIONS DRUG-DELIVERY MESOPOROUS SILICON CLICK CHEMISTRY ENHANCED PERMEABILITY PARTICLES NANOCARRIERS STABILITY KINETICS CARRIER 116 Chemical sciences |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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