Fecal pollution can explain antibiotic resistance gene abundances in anthropogenically impacted environments

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http://hdl.handle.net/10138/310790

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Karkman , A , Parnanen , K & Larsson , D G J 2019 , ' Fecal pollution can explain antibiotic resistance gene abundances in anthropogenically impacted environments ' , Nature Communications , vol. 10 , 80 . https://doi.org/10.1038/s41467-018-07992-3

Title: Fecal pollution can explain antibiotic resistance gene abundances in anthropogenically impacted environments
Author: Karkman, Antti; Parnanen, Katariina; Larsson, D. G. Joakim
Contributor: University of Helsinki, Organismal and Evolutionary Biology Research Programme
University of Helsinki, Antibiotic resistance in human impacted environments
Date: 2019-01-08
Language: eng
Number of pages: 8
Belongs to series: Nature Communications
ISSN: 2041-1723
URI: http://hdl.handle.net/10138/310790
Abstract: Discharge of treated sewage leads to release of antibiotic resistant bacteria, resistance genes and antibiotic residues to the environment. However, it is unclear whether increased abundance of antibiotic resistance genes in sewage and sewage-impacted environments is due to on-site selection pressure by residual antibiotics, or is simply a result of fecal contamination with resistant bacteria. Here we analyze relative resistance gene abundance and accompanying extent of fecal pollution in publicly available metagenomic data, using crAssphage sequences as a marker of human fecal contamination (crAssphage is a bacteriophage that is exceptionally abundant in, and specific to, human feces). We find that the presence of resistance genes can largely be explained by fecal pollution, with no clear signs of selection in the environment, with the exception of environments polluted by very high levels of anti-biotics from manufacturing, where selection is evident. Our results demonstrate the necessity to take into account fecal pollution levels to avoid making erroneous assumptions regarding environmental selection of antibiotic resistance.
Subject: WATER TREATMENT PLANTS
STORM-DRAIN OUTFALLS
WASTE-WATER
ESCHERICHIA-COLI
READ ALIGNMENT
CRASSPHAGE
MICROBIOME
TRACKING
BACTERIA
REVEALS
1172 Environmental sciences
3142 Public health care science, environmental and occupational health
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