Fecal pollution can explain antibiotic resistance gene abundances in anthropogenically impacted environments

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dc.contributor.author Karkman, Antti
dc.contributor.author Parnanen, Katariina
dc.contributor.author Larsson, D. G. Joakim
dc.date.accessioned 2020-01-31T13:09:01Z
dc.date.available 2020-01-31T13:09:01Z
dc.date.issued 2019-01-08
dc.identifier.citation Karkman , A , Parnanen , K & Larsson , D G J 2019 , ' Fecal pollution can explain antibiotic resistance gene abundances in anthropogenically impacted environments ' , Nature Communications , vol. 10 , 80 . https://doi.org/10.1038/s41467-018-07992-3
dc.identifier.other PURE: 121489967
dc.identifier.other PURE UUID: 5d680599-9a41-4e0f-b7b3-c8f4c6f37dde
dc.identifier.other WOS: 000455102900019
dc.identifier.other Scopus: 85059743117
dc.identifier.other ORCID: /0000-0003-0983-3319/work/68616846
dc.identifier.uri http://hdl.handle.net/10138/310790
dc.description.abstract Discharge of treated sewage leads to release of antibiotic resistant bacteria, resistance genes and antibiotic residues to the environment. However, it is unclear whether increased abundance of antibiotic resistance genes in sewage and sewage-impacted environments is due to on-site selection pressure by residual antibiotics, or is simply a result of fecal contamination with resistant bacteria. Here we analyze relative resistance gene abundance and accompanying extent of fecal pollution in publicly available metagenomic data, using crAssphage sequences as a marker of human fecal contamination (crAssphage is a bacteriophage that is exceptionally abundant in, and specific to, human feces). We find that the presence of resistance genes can largely be explained by fecal pollution, with no clear signs of selection in the environment, with the exception of environments polluted by very high levels of anti-biotics from manufacturing, where selection is evident. Our results demonstrate the necessity to take into account fecal pollution levels to avoid making erroneous assumptions regarding environmental selection of antibiotic resistance. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Nature Communications
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject WASTE-WATER
dc.subject CRASSPHAGE
dc.subject MICROBIOME
dc.subject TRACKING
dc.subject BACTERIA
dc.subject REVEALS
dc.subject 1172 Environmental sciences
dc.subject 3142 Public health care science, environmental and occupational health
dc.title Fecal pollution can explain antibiotic resistance gene abundances in anthropogenically impacted environments en
dc.type Article
dc.contributor.organization Organismal and Evolutionary Biology Research Programme
dc.contributor.organization Antibiotic resistance in human impacted environments
dc.contributor.organization Department of Microbiology
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1038/s41467-018-07992-3
dc.relation.issn 2041-1723
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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