One-Year Follow-up Study Detects Myocardial Changes with Cardiovascular Magnetic Resonance Tagging in Active Rheumatoid Arthritis

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Lehmonen , L , Vuorinen , A-M , Koivuniemi , R , Leirisalo-Repo , M , Holmström , M M , Kivistö , S & Kaasalainen , T 2018 , ' One-Year Follow-up Study Detects Myocardial Changes with Cardiovascular Magnetic Resonance Tagging in Active Rheumatoid Arthritis ' , Academic Radiology , vol. 25 , no. 4 , pp. 476-485 . https://doi.org/10.1016/j.acra.2017.10.017

Title: One-Year Follow-up Study Detects Myocardial Changes with Cardiovascular Magnetic Resonance Tagging in Active Rheumatoid Arthritis
Author: Lehmonen, Lauri; Vuorinen, Aino-Maija; Koivuniemi, Riitta; Leirisalo-Repo, Marjatta; Holmström, Miia Maria; Kivistö, Sari; Kaasalainen, Touko
Contributor organization: Department of Physics
Clinicum
Department of Diagnostics and Therapeutics
University of Helsinki
HUS Medical Imaging Center
Reumatologian yksikkö
Department of Medicine
HUS Inflammation Center
HUS Internal Medicine and Rehabilitation
Date: 2018-04
Language: eng
Number of pages: 10
Belongs to series: Academic Radiology
ISSN: 1076-6332
DOI: https://doi.org/10.1016/j.acra.2017.10.017
URI: http://hdl.handle.net/10138/310827
Abstract: RATIONALE AND OBJECTIVES: To evaluate the effects of 1 year of medical treatment on myocardial function in active rheumatoid arthritis (RA). MATERIALS AND METHODS: Thirty-nine female patients with RA without any known cardiovascular disease underwent a cardiovascular magnetic resonance (CMR) examination before and after 1 year of antirheumatic treatment. The population comprised untreated active early RA (ERA) and chronic RA patients, who were grouped accordingly. The CMR protocol included volumetric determinations, late gadolinium enhancement imaging, myocardial tagging, and native T1 mapping. DAS28-CRP disease activity scores were calculated before and after the treatment. RESULTS: Results are reported as median (quartile 1-quartile 3). Time to peak diastolic filling rate improved in ERA (495 [443-561] ms vs 441 [340-518] ms, P = .018). Peak diastolic mean mid short-axis circumferential strain rate of all six segments was improved (82 [74-91] %/s vs 91 [77-100] %/s, P = .05), particularly in the anterior segment (82 [63-98] %/s vs 86 [77-109] %/s, P = .013). DAS28-CRP decreased in ERA (3.8 [3.2-4.1] vs 1.6 [1.4-2.2], P < .001). In chronic RA, no statistically significant improvement was detected. CONCLUSIONS: Early treatment of active RA is important, as myocardial function detected with CMR tagging improved in ERA in parallel with decreasing inflammatory activity.
Subject: 114 Physical sciences
3126 Surgery, anesthesiology, intensive care, radiology
Cardiovascular magnetic resonance imaging
tagging
strain
rheumatoid arthritis
HEART-FAILURE
ASYMPTOMATIC INDIVIDUALS
CIRCUMFERENTIAL STRAIN
DIASTOLIC DYSFUNCTION
INCREASED PREVALENCE
PROGNOSTIC VALUE
ATHEROSCLEROSIS
INVOLVEMENT
CMR
ECHOCARDIOGRAPHY
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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