Comparison of Umbilical Serum Copeptin Relative to Erythropoietin and S100B as Asphyxia Biomarkers at Birth

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Summanen , M , Seikku , L , Rahkonen , P , Stefanovic , V , Teramo , K , Andersson , S , Kaila , K & Rahkonen , L 2017 , ' Comparison of Umbilical Serum Copeptin Relative to Erythropoietin and S100B as Asphyxia Biomarkers at Birth ' , Neonatology , vol. 112 , no. 1 , pp. 60-66 . https://doi.org/10.1159/000456063

Title: Comparison of Umbilical Serum Copeptin Relative to Erythropoietin and S100B as Asphyxia Biomarkers at Birth
Author: Summanen, Milla; Seikku, Laura; Rahkonen, Petri; Stefanovic, Vedran; Teramo, Kari; Andersson, Sture; Kaila, Kai; Rahkonen, Leena
Contributor organization: Laboratory of Neurobiology
University of Helsinki
Biosciences
Neuroscience Center
Helsinki Institute of Life Science HiLIFE
Department of Obstetrics and Gynecology
HUS Gynecology and Obstetrics
HUS Children and Adolescents
Children's Hospital
Clinicum
Kai Kaila / Principal Investigator
Physiology and Neuroscience (-2020)
Date: 2017
Language: eng
Number of pages: 7
Belongs to series: Neonatology
ISSN: 1661-7800
DOI: https://doi.org/10.1159/000456063
URI: http://hdl.handle.net/10138/310867
Abstract: Background: Birth asphyxia, estimated to account for a million neonatal deaths annually, can cause a wide variety of neurodevelopmental impairments. There is a need to develop new, swift methods to identify those neonates who would benefit from neuroprotective treatments such as hypothermia. Objectives: To examine the utility of cord serum copeptin, a stable byproduct of arginine vasopressin release, as a biomarker of birth asphyxia based on a comparison with 2 biomarkers of hypoxia and brain trauma: erythropoietin and S100B. Methods: The study population consisted of 140 singleton, term neonates: 113 controls and 27 with birth asphyxia (2/3 criteria met: umbilical artery pH
Subject: Neonate
Birth asphyxia
Arginine vasopressin
Copeptin
Erythropoietin
S100B
AMNIOTIC-FLUID ERYTHROPOIETIN
PLASMA COPEPTIN
BRAIN-DAMAGE
CORD BLOOD
VASOPRESSIN
INFANTS
ENCEPHALOPATHY
FETAL
3111 Biomedicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion


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