Moyamoya vasculopathy - Patient demographics and characteristics in the Finnish population

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http://hdl.handle.net/10138/310909

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Saarela , M , Mustanoja , S , Pekkola , J , Tyni , T , Hernesniemi , J , Kivipelto , L & Tatlisumak , T 2017 , ' Moyamoya vasculopathy - Patient demographics and characteristics in the Finnish population ' , International Journal of Stroke , vol. 12 , no. 1 , pp. 90-95 . https://doi.org/10.1177/1747493016669847

Title: Moyamoya vasculopathy - Patient demographics and characteristics in the Finnish population
Author: Saarela, Marika; Mustanoja, Satu; Pekkola, Johanna; Tyni, Tiina; Hernesniemi, Juha; Kivipelto, Leena; Tatlisumak, Turgut
Other contributor: University of Helsinki, Neurologian yksikkö
University of Helsinki, Department of Neurosciences
University of Helsinki, Clinicum
University of Helsinki, Lastenneurologian yksikkö
University of Helsinki, Clinicum
University of Helsinki, Neurokirurgian yksikkö
University of Helsinki, HUS Neurocenter









Date: 2017-01
Language: eng
Number of pages: 6
Belongs to series: International Journal of Stroke
ISSN: 1747-4930
DOI: https://doi.org/10.1177/1747493016669847
URI: http://hdl.handle.net/10138/310909
Abstract: Background and purpose Moyamoya vasculopathy, a rare steno-occlusive progressive cerebrovascular disorder, has not been thoroughly studied in Caucasian populations. We established a registry of Finnish patients treated at the Helsinki University Hospital, to collect and report demographic and clinical data. Methods We collected data both retrospectively and prospectively from all the patients with a moyamoya vasculopathy referred to our hospital between January 1987 and December 2014. All patients underwent a neurological outpatient clinic visit. Results We diagnosed 61 patients (50 females, 10 children) with moyamoya vasculopathy. The mean age at the disease-onset was 31.517.9 years. The two most common presenting symptoms were ischemic stroke (n=31) and hemorrhage (n=8). Forty-four percent underwent revascularization surgery, and 70% were prescribed antithrombotic treatment. Conclusions The results support in part the Western phenotype of the disease considering the later presentation and larger female predominance compared to the Asian moyamoya vasculopathy reports. However, the proportion of ischemic strokes and hemorrhagic strokes is closer to Japanese population than German population. The absence of familial cases points to a different genetic profile in the Finnish patients.
Subject: Moyamoya
ischemic stroke
hemorrhagic stroke
epidemiology
clinical characteristics
vasculopathy
EPIDEMIOLOGIC FEATURES
DISEASE
JAPAN
3124 Neurology and psychiatry
3126 Surgery, anesthesiology, intensive care, radiology
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