Two novel genomic regions associated with fearfulness in dogs overlap human neuropsychiatric loci

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dc.contributor University of Helsinki, Veterinary Biosciences en
dc.contributor University of Helsinki, Veterinary Biosciences en
dc.contributor University of Helsinki, Departments of Faculty of Veterinary Medicine en
dc.contributor University of Helsinki, Hannes Tapani Lohi / Principal Investigator en
dc.contributor University of Helsinki, Organismal and Evolutionary Biology Research Programme en
dc.contributor University of Helsinki, Hannes Tapani Lohi / Principal Investigator en
dc.contributor University of Helsinki, Helsinki One Health (HOH) en
dc.contributor.author Sarviaho, Riika
dc.contributor.author Hakosalo, Osmo Topi Valtteri
dc.contributor.author Tiira, Katriina
dc.contributor.author Sulkama, Sini
dc.contributor.author Salmela, Elina
dc.contributor.author Hytönen, Marjo Kristiina
dc.contributor.author Sillanpää, Mikko
dc.contributor.author Lohi, Hannes
dc.date.accessioned 2020-02-04T10:58:02Z
dc.date.available 2020-02-04T10:58:02Z
dc.date.issued 2019
dc.identifier.citation Sarviaho , R , Hakosalo , O T V , Tiira , K , Sulkama , S , Salmela , E , Hytönen , M K , Sillanpää , M & Lohi , H 2019 , ' Two novel genomic regions associated with fearfulness in dogs overlap human neuropsychiatric loci ' , Translational Psychiatry , vol. 9 , no. 18 . https://doi.org/10.1038/s41398-018-0361-x en
dc.identifier.issn 2158-3188
dc.identifier.other PURE: 130150270
dc.identifier.other PURE UUID: d96d4786-9f4e-4edc-9c45-bff9fc7fffc1
dc.identifier.other WOS: 000455917900003
dc.identifier.other ORCID: /0000-0003-1976-5874/work/80222243
dc.identifier.uri http://hdl.handle.net/10138/310969
dc.description.abstract Anxiety disorders are among the leading health issues in human medicine. The complex phenotypic and allelic nature of these traits as well as the challenge of establishing reliable measures of the heritable component of behaviour from the associated environmental factors hampers progress in their molecular aetiology. Dogs exhibit large natural variation in fearful and anxious behaviour and could facilitate progress in the molecular aetiology due to their unique genetic architecture. We have performed a genome-wide association study with a canine high-density SNP array in a cohort of 330 German Shepherds for two phenotypes, fear of loud noises (noise sensitivity) and fear of strangers or in novel situations. Genome-widely significant loci were discovered for the traits on chromosomes 20 and 7, respectively. The regions overlap human neuropsychiatric loci, including 18p11.2, with physiologically relevant candidate genes that contribute to glutamatergic and dopaminergic neurotransmission in the brain. In addition, the noise-sensitivity locus includes hearing-related candidate genes. These results indicate a genetic contribution for canine fear and suggest a shared molecular aetiology of anxiety across species. Further characterisation of the identified loci will pave the way to molecular understanding of the conditions as a prerequisite for improved therapy. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Translational Psychiatry
dc.rights en
dc.subject 3124 Neurology and psychiatry en
dc.title Two novel genomic regions associated with fearfulness in dogs overlap human neuropsychiatric loci en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1038/s41398-018-0361-x
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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