Clinical findings in 25 patients with sinonasal or nasopharyngeal extramedullary plasmacytoma in a four-decade single-centre series

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Vento , S I , Vähämurto , P , Silventoinen , K , Karjalainen-Lindsberg , M-L , Mannisto , S , Leppa , S & Makitie , A A 2017 , ' Clinical findings in 25 patients with sinonasal or nasopharyngeal extramedullary plasmacytoma in a four-decade single-centre series ' , Acta Oto-Laryngologica , vol. 137 , no. 9 , pp. 975-980 . https://doi.org/10.1080/00016489.2017.1325514

Title: Clinical findings in 25 patients with sinonasal or nasopharyngeal extramedullary plasmacytoma in a four-decade single-centre series
Author: Vento, Seija Inkeri; Vähämurto, Pauli; Silventoinen, Kaija; Karjalainen-Lindsberg, Marja-Liisa; Mannisto, Susanna; Leppa, Sirpa; Makitie, Antti Aarni
Contributor organization: Clinicum
Korva-, nenä- ja kurkkutautien klinikka
Medicum
Department of Pathology
University of Helsinki
Research Programs Unit
Department of Oncology
Genome-Scale Biology (GSB) Research Program
Sirpa Marianne Leppä / Principal Investigator
HUS Head and Neck Center
HUS Comprehensive Cancer Center
Date: 2017
Language: eng
Number of pages: 6
Belongs to series: Acta Oto-Laryngologica
ISSN: 0001-6489
DOI: https://doi.org/10.1080/00016489.2017.1325514
URI: http://hdl.handle.net/10138/310990
Abstract: Objectives: Extramedullary plasmacytoma in the sinonasal tract or nasopharynx is rare. The aim of the study was to review data on symptoms, clinical findings, treatment and follow-up of plasmacytomas in the sinonasal and nasopharyngeal regions in order to delineate the main clinical characteristics and the optimal management. Method: Twenty-five patients with sinonasal or nasopharyngeal plasmacytoma, diagnosed and treated at the Helsinki University Hospital during a 39-year period from 1975 to 2013 were retrospectively reviewed. Results: There were 18 males and 7 females with a median age of 66 years (range, 36-80). Sixty-eight percent received only radiotherapy or (chemo)radiotherapy. Forty-seven percent of them had a complete response to primary radiotherapy and one patient had a complete response after receiving additional brachytherapy. Four patients were treated primarily with surgery only. Two of them had a local recurrence, but were then successfully treated with radiotherapy. Altogether, four patients received a combination of surgery and (chemo)radiotherapy. Forty-four percent were alive with no evidence of disease after a median follow-up time of 78 months. Forty percent died of their disease and 16% died of other causes. Conclusions: Our study supports radiotherapy as a treatment of choice, but for small tumours surgery alone or in combination with radiotherapy may also be considered. Chinese abstract
Subject: Extramedullary plasmacytoma
sinonasal
nasopharynx
multiple myeloma
radiotherapy
SOLITARY PLASMACYTOMA
NECK REGION
HEAD
RADIOTHERAPY
BONE
3125 Otorhinolaryngology, ophthalmology
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion


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