FunMappOne : a tool to hierarchically organize and visually navigate functional gene annotations in multiple experiments

Show simple item record Scala, Giovanni Serra, Angela Marwah, Veer Singh Saarimaki, Laura Aliisa Greco, Dario 2020-02-05T09:28:02Z 2020-02-05T09:28:02Z 2019-02-15
dc.identifier.citation Scala , G , Serra , A , Marwah , V S , Saarimaki , L A & Greco , D 2019 , ' FunMappOne : a tool to hierarchically organize and visually navigate functional gene annotations in multiple experiments ' , BMC Bioinformatics , vol. 20 , 79 .
dc.identifier.other PURE: 131470079
dc.identifier.other PURE UUID: 65dbf720-d949-4893-b46f-085ffc0ee688
dc.identifier.other WOS: 000458847500002
dc.identifier.other ORCID: /0000-0001-9195-9003/work/68614858
dc.description.abstract BackgroundFunctional annotation of genes is an essential step in omics data analysis. Multiple databases and methods are currently available to summarize the functions of sets of genes into higher level representations, such as ontologies and molecular pathways. Annotating results from omics experiments into functional categories is essential not only to understand the underlying regulatory dynamics but also to compare multiple experimental conditions at a higher level of abstraction. Several tools are already available to the community to represent and compare functional profiles of omics experiments. However, when the number of experiments and/or enriched functional terms is high, it becomes difficult to interpret the results even when graphically represented. Therefore, there is currently a need for interactive and user-friendly tools to graphically navigate and further summarize annotations in order to facilitate results interpretation also when the dimensionality is high.ResultsWe developed an approach that exploits the intrinsic hierarchical structure of several functional annotations to summarize the results obtained through enrichment analyses to higher levels of interpretation and to map gene related information at each summarized level. We built a user-friendly graphical interface that allows to visualize the functional annotations of one or multiple experiments at once. The tool is implemented as a R-Shiny application called FunMappOne and is available at is a R-shiny graphical tool that takes in input multiple lists of human or mouse genes, optionally along with their related modification magnitudes, computes the enriched annotations from Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, or Reactome databases, and reports interactive maps of functional terms and pathways organized in rational groups. FunMappOne allows a fast and convenient comparison of multiple experiments and an easy way to interpret results. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof BMC Bioinformatics
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Functional annotation
dc.subject Pathway visualization
dc.subject Ontology visualization
dc.subject KEGG
dc.subject Gene Ontology
dc.subject Reactome
dc.subject R-Shiny
dc.subject R PACKAGE
dc.subject LISTS
dc.subject 1182 Biochemistry, cell and molecular biology
dc.subject 1184 Genetics, developmental biology, physiology
dc.title FunMappOne : a tool to hierarchically organize and visually navigate functional gene annotations in multiple experiments en
dc.type Article
dc.contributor.organization Institute of Biotechnology
dc.contributor.organization Research Programs Unit
dc.description.reviewstatus Peer reviewed
dc.relation.issn 1471-2105
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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