Dietary phosphorus intake is negatively associated with bone formation among women and positively associated with some bone traits among men-a cross-sectional study in middle-aged Caucasians

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Itkonen , S T , Rita , H J , Saarnio , E M , Kemi , V E , Karp , H J , Kärkkäinen , M , Pekkinen , M H , Laitinen , E K , Risteli , J , Koivula , M-K , Sievanen , H & Lamberg-Allardt , C J E 2017 , ' Dietary phosphorus intake is negatively associated with bone formation among women and positively associated with some bone traits among men-a cross-sectional study in middle-aged Caucasians ' , Nutrition Research , vol. 37 , pp. 58-66 . https://doi.org/10.1016/j.nutres.2016.12.009

Title: Dietary phosphorus intake is negatively associated with bone formation among women and positively associated with some bone traits among men-a cross-sectional study in middle-aged Caucasians
Author: Itkonen, Suvi T.; Rita, Hannu J.; Saarnio, Elisa M.; Kemi, Virpi E.; Karp, Heini J.; Kärkkäinen, Merja; Pekkinen, Minna H.; Laitinen, E. Kalevi; Risteli, Juha; Koivula, Marja-Kaisa; Sievanen, Harri; Lamberg-Allardt, Christel J. E.
Contributor organization: University of Helsinki
Department of Food and Nutrition
Department of Forest Sciences
Christel Lamberg-Allardt / Research Group
Clinicum
Department of Obstetrics and Gynecology
Viikki Molecular Nutrition Group
HUS Gynecology and Obstetrics
Date: 2017-01
Language: eng
Number of pages: 9
Belongs to series: Nutrition Research
ISSN: 0271-5317
DOI: https://doi.org/10.1016/j.nutres.2016.12.009
URI: http://hdl.handle.net/10138/311145
Abstract: High dietary phosphorus (P) intake has acute negative effects on calcium (Ca) and bone metabolism, but long-term clinical data are contradictory. We hypothesized that high P intake is associated with impaired bone health as suggested by earlier short-term studies on bone metabolism. In this cross-sectional study, we investigated associations between dietary P intake, bone traits in the radius and tibia, and bone turnover in a population-based sample of 37- to 47-year-old Caucasian premenopausal women (n = 333) and men (n = 179) living in Southern Finland (60 degrees N). We used various regression models in an "elaboration approach" to elucidate the role of P intake in bone traits and turnover. The addition of relevant covariates to the models mainly removed the significance of P intake as a determinant of bone traits. In the final regression model (P intake, weight, height, age, Ca intake, serum 25-hydroxyvitamin D, physical activity, smoking, contraceptive use in women), P intake was slightly positively associated only with bone mineral content and cross-sectional cortical bone area in the tibia of men. Among women, inclusion of Ca removed all existing significance in the crude models for any bone trait. In women P intake was negatively associated with the bone formation marker serum intact pro-collagen type I amino-terminal propeptide, whereas no association was present between P intake and bone turnover in men. In conclusion, these findings disagree with the hypothesis; P intake was not deleteriously associated with bone traits; however, P intake may negatively contribute to bone formation among women. (C) 2016 Elsevier Inc. All rights reserved.
Subject: Phosphorus
Calcium
Bone mineral density
Bone turnover markers
Peripheral quantitative computed tomography
Cross-sectional study
PARATHYROID-HORMONE SECRETION
MINERAL DENSITY
YOUNG-WOMEN
PHOSPHATE ADDITIVES
PHYSICAL-ACTIVITY
JAPANESE WOMEN
CALCIUM INTAKE
RISK-FACTOR
OSTEOPOROSIS
PERFORMANCE
416 Food Science
1172 Environmental sciences
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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