Dietary phosphorus intake is negatively associated with bone formation among women and positively associated with some bone traits among men-a cross-sectional study in middle-aged Caucasians

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Itkonen , S T , Rita , H J , Saarnio , E M , Kemi , V E , Karp , H J , Kärkkäinen , M , Pekkinen , M H , Laitinen , E K , Risteli , J , Koivula , M-K , Sievanen , H & Lamberg-Allardt , C J E 2017 , ' Dietary phosphorus intake is negatively associated with bone formation among women and positively associated with some bone traits among men-a cross-sectional study in middle-aged Caucasians ' , Nutrition Research , vol. 37 , pp. 58-66 . https://doi.org/10.1016/j.nutres.2016.12.009

Title: Dietary phosphorus intake is negatively associated with bone formation among women and positively associated with some bone traits among men-a cross-sectional study in middle-aged Caucasians
Author: Itkonen, Suvi T.; Rita, Hannu J.; Saarnio, Elisa M.; Kemi, Virpi E.; Karp, Heini J.; Kärkkäinen, Merja; Pekkinen, Minna H.; Laitinen, E. Kalevi; Risteli, Juha; Koivula, Marja-Kaisa; Sievanen, Harri; Lamberg-Allardt, Christel J. E.
Contributor: University of Helsinki, University of Helsinki
University of Helsinki, University of Helsinki
University of Helsinki, University of Helsinki
University of Helsinki, Department of Food and Nutrition
University of Helsinki, Department of Food and Nutrition
University of Helsinki, Department of Food and Nutrition
University of Helsinki, University of Helsinki
University of Helsinki, University of Helsinki
Date: 2017-01
Language: eng
Number of pages: 9
Belongs to series: Nutrition Research
ISSN: 0271-5317
URI: http://hdl.handle.net/10138/311145
Abstract: High dietary phosphorus (P) intake has acute negative effects on calcium (Ca) and bone metabolism, but long-term clinical data are contradictory. We hypothesized that high P intake is associated with impaired bone health as suggested by earlier short-term studies on bone metabolism. In this cross-sectional study, we investigated associations between dietary P intake, bone traits in the radius and tibia, and bone turnover in a population-based sample of 37- to 47-year-old Caucasian premenopausal women (n = 333) and men (n = 179) living in Southern Finland (60 degrees N). We used various regression models in an "elaboration approach" to elucidate the role of P intake in bone traits and turnover. The addition of relevant covariates to the models mainly removed the significance of P intake as a determinant of bone traits. In the final regression model (P intake, weight, height, age, Ca intake, serum 25-hydroxyvitamin D, physical activity, smoking, contraceptive use in women), P intake was slightly positively associated only with bone mineral content and cross-sectional cortical bone area in the tibia of men. Among women, inclusion of Ca removed all existing significance in the crude models for any bone trait. In women P intake was negatively associated with the bone formation marker serum intact pro-collagen type I amino-terminal propeptide, whereas no association was present between P intake and bone turnover in men. In conclusion, these findings disagree with the hypothesis; P intake was not deleteriously associated with bone traits; however, P intake may negatively contribute to bone formation among women. (C) 2016 Elsevier Inc. All rights reserved.
Subject: Phosphorus
Calcium
Bone mineral density
Bone turnover markers
Peripheral quantitative computed tomography
Cross-sectional study
PARATHYROID-HORMONE SECRETION
MINERAL DENSITY
YOUNG-WOMEN
PHOSPHATE ADDITIVES
PHYSICAL-ACTIVITY
JAPANESE WOMEN
CALCIUM INTAKE
RISK-FACTOR
OSTEOPOROSIS
PERFORMANCE
416 Food Science
1172 Environmental sciences
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