Wasik , A A , Dash , S N & Lehtonen , S 2019 , ' Septins in kidney : A territory little explored ' , Cytoskeleton , vol. 76 , no. 1 , pp. 154-162 . https://doi.org/10.1002/cm.21477
Title: | Septins in kidney : A territory little explored |
Author: | Wasik, Anita A.; Dash, Surjya N.; Lehtonen, Sanna |
Contributor organization: | Sanna Lehtonen research group Department of Pathology University of Helsinki |
Date: | 2019-01 |
Language: | eng |
Number of pages: | 9 |
Belongs to series: | Cytoskeleton |
ISSN: | 1949-3584 |
DOI: | https://doi.org/10.1002/cm.21477 |
URI: | http://hdl.handle.net/10138/311168 |
Abstract: | Septins are a conserved family of GTP-binding proteins that assemble into cytoskeletal filaments to function in a highly sophisticated and physiologically regulated manner. Originally septins were discovered in the budding yeast as membrane-associated filaments that affect cell polarity and cytokinesis. In the last decades, much progress has been made in understanding the biochemical properties and cell biological functions of septins. In line with this, mammalian septins have been shown to be involved in various cellular processes, including regulation of cell polarity, cytoskeletal organization, vesicle trafficking, ciliogenesis, and cell-pathogen interactions. A growing number of studies have shown that septins play important roles in tissue and organ development and physiology; yet, little is known about their role in the kidney. In the following review, we discuss the structure and functions of septins in general and summarize the evidence for their presence and roles in the kidney. |
Subject: |
ciliogenesis
cytoskeleton kidney septins zebrafish PRIMARY CILIUM MAMMALIAN SEPTIN ZEBRAFISH PRONEPHROS FILAMENT FORMATION KUPFFERS VESICLE MYOSIN-II CELL PROTEIN COMPLEX ORGANIZATION 3111 Biomedicine 1182 Biochemistry, cell and molecular biology |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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