Septins in kidney : A territory little explored

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http://hdl.handle.net/10138/311168

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Wasik , A A , Dash , S N & Lehtonen , S 2019 , ' Septins in kidney : A territory little explored ' , Cytoskeleton , vol. 76 , no. 1 , pp. 154-162 . https://doi.org/10.1002/cm.21477

Title: Septins in kidney : A territory little explored
Author: Wasik, Anita A.; Dash, Surjya N.; Lehtonen, Sanna
Contributor: University of Helsinki, Sanna Lehtonen research group
University of Helsinki, Department of Pathology
University of Helsinki, Department of Pathology
Date: 2019-01
Language: eng
Number of pages: 9
Belongs to series: Cytoskeleton
ISSN: 1949-3584
URI: http://hdl.handle.net/10138/311168
Abstract: Septins are a conserved family of GTP-binding proteins that assemble into cytoskeletal filaments to function in a highly sophisticated and physiologically regulated manner. Originally septins were discovered in the budding yeast as membrane-associated filaments that affect cell polarity and cytokinesis. In the last decades, much progress has been made in understanding the biochemical properties and cell biological functions of septins. In line with this, mammalian septins have been shown to be involved in various cellular processes, including regulation of cell polarity, cytoskeletal organization, vesicle trafficking, ciliogenesis, and cell-pathogen interactions. A growing number of studies have shown that septins play important roles in tissue and organ development and physiology; yet, little is known about their role in the kidney. In the following review, we discuss the structure and functions of septins in general and summarize the evidence for their presence and roles in the kidney.
Subject: ciliogenesis
cytoskeleton
kidney
septins
zebrafish
PRIMARY CILIUM
MAMMALIAN SEPTIN
ZEBRAFISH PRONEPHROS
FILAMENT FORMATION
KUPFFERS VESICLE
MYOSIN-II
CELL
PROTEIN
COMPLEX
ORGANIZATION
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
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