Nano-sized zinc oxide and silver, but not titanium dioxide, induce innate and adaptive immunity and antiviral response in differentiated THP-1 cells

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Poon , W L , Alenius , H , Ndika , J , Fortino , V , Kolhinen , V , Mesceriakovas , A , Wang , M , Greco , D , Lähde , A , Jokiniemi , J , Lee , J C-Y , El-Nezami , H & Karisola , P 2017 , ' Nano-sized zinc oxide and silver, but not titanium dioxide, induce innate and adaptive immunity and antiviral response in differentiated THP-1 cells ' , Nanotoxicology , vol. 11 , no. 7 , pp. 936-951 . https://doi.org/10.1080/17435390.2017.1382600

Title: Nano-sized zinc oxide and silver, but not titanium dioxide, induce innate and adaptive immunity and antiviral response in differentiated THP-1 cells
Author: Poon, W. L.; Alenius, Harri; Ndika, Joseph; Fortino, Vittorio; Kolhinen, Vesa; Mesceriakovas, Arunas; Wang, Mingfu; Greco, Dario; Lähde, Anna; Jokiniemi, Jorma; Lee, Jetty Chung-Yung; El-Nezami, Hani; Karisola, Piia
Contributor: University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Institute of Biotechnology
University of Helsinki, Institute of Biotechnology
University of Helsinki, Medicum
Date: 2017
Language: eng
Number of pages: 16
Belongs to series: Nanotoxicology
ISSN: 1743-5390
URI: http://hdl.handle.net/10138/311282
Abstract: Nano-sized metal oxides are currently the most manufactured nanomaterials (NMs), and are increasingly used in consumer products. Recent exposure data reveal a genuine potential for adverse health outcomes for a vast array of NMs, however the underlying mechanisms are not fully understood. To elucidate size-related molecular effects, differentiated THP-1 cells were exposed to nano-sized materials (n-TiO2, n-ZnO and n-Ag), or their bulk-sized (b-ZnO and b-TiO2) or ionic (i-Ag) counterparts, and genome-wide gene expression changes were studied at low-toxic concentrations (
Subject: ZnO
Ag
nanomaterials
immune system
transcriptomics
INFLAMMASOME ACTIVATION
NALP3 INFLAMMASOME
NANOPARTICLES
NANOMATERIALS
MONOCYTES
TOXICITY
IFIT1
3111 Biomedicine
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