Diverse functions for different forms of nuclear actin

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Virtanen , J A & Vartiainen , M K 2017 , ' Diverse functions for different forms of nuclear actin ' , Current Opinion in Cell Biology , vol. 46 , pp. 33-38 . https://doi.org/10.1016/j.ceb.2016.12.004

Title: Diverse functions for different forms of nuclear actin
Author: Virtanen, Jori A.; Vartiainen, Maria K.
Contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Institute of Biotechnology
Date: 2017-06
Language: eng
Number of pages: 6
Belongs to series: Current Opinion in Cell Biology
ISSN: 0955-0674
URI: http://hdl.handle.net/10138/311302
Abstract: In addition to its essential roles as part of the cytoskeleton, actin has also been linked to many processes in the nucleus. Recent data has demonstrated the presence of both monomeric and polymeric actin in the nucleus, and implied distinct functional roles for these actin pools. Monomeric actin seems to be involved in regulation of gene expression through transcription factors, chromatin regulating complexes and RNA polymerases. In addition to cytoplasmic actin regulators, nuclear proteins, such as emerin, can regulate actin polymerization properties specifically in this compartment. Besides of structural roles, nuclear actin filaments may be required for organizing the nuclear contents and for the maintenance of genomic integrity.
Subject: RNA-POLYMERASE-II
DEPENDENT TRANSCRIPTION
COMPLEX
REVEALS
CELLS
COACTIVATOR
STABILIZES
ACTIVATION
FILAMENTS
PROTEINS
1182 Biochemistry, cell and molecular biology
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