Clinical and MRI Features of Cerebral Small-Vessel Disease in Type 1 Diabetes

Show full item record



Permalink

http://hdl.handle.net/10138/311320

Citation

Thorn , L M , Shams , S , Gordin , D , Liebkind , R , Forsblom , C , Summanen , P , Hägg-Holmberg , S , Tatlisumak , T , Salonen , O , Putaala , J , Martola , J & Groop , P-H 2019 , ' Clinical and MRI Features of Cerebral Small-Vessel Disease in Type 1 Diabetes ' , Diabetes Care , vol. 42 , no. 2 , pp. 327-330 . https://doi.org/10.2337/dc18-1302

Title: Clinical and MRI Features of Cerebral Small-Vessel Disease in Type 1 Diabetes
Author: Thorn, Lena M.; Shams, Sara; Gordin, Daniel; Liebkind, Ron; Forsblom, Carol; Summanen, Paula; Hägg-Holmberg, Stefanie; Tatlisumak, Turgut; Salonen, Oili; Putaala, Jukka; Martola, Juha; Groop, Per-Henrik
Contributor: University of Helsinki, Nefrologian yksikkö
University of Helsinki, Clinicum
University of Helsinki, Neurologian yksikkö
University of Helsinki, Research Programs Unit
University of Helsinki, HUS Head and Neck Center
University of Helsinki, Nefrologian yksikkö
University of Helsinki, HUS Neurocenter
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Department of Neurosciences
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Research Programs Unit
Date: 2019-02-01
Language: eng
Number of pages: 4
Belongs to series: Diabetes Care
ISSN: 0149-5992
URI: http://hdl.handle.net/10138/311320
Abstract: OBJECTIVETo assess the prevalence of cerebral small-vessel disease (SVD) in subjects with type 1 diabetes compared with healthy control subjects and to characterize the diabetes-related factors associated with SVD.RESEARCH DESIGN AND METHODSThis substudy was cross-sectional in design and included 191 participants with type 1 diabetes and median age 40.0 years (interquartile range 33.0-45.1) and 30 healthy age- and sex-matched control subjects. All participants underwent clinical investigation and brain MRIs, assessed for cerebral SVD.RESULTSCerebral SVD was more common in participants with type 1 diabetes than in healthy control subjects: any marker 35% vs. 10% (P = 0.005), cerebral microbleeds (CMBs) 24% vs. 3.3% (P = 0.008), white matter hyperintensities 17% vs. 6.7% (P = 0.182), and lacunes 2.1% vs. 0% (P = 1.000). Presence of CMBs was independently associated with systolic blood pressure (odds ratio 1.03 [95% CI 1.00-1.05], P = 0.035).CONCLUSIONSCerebral SVD, CMBs in particular, is more common in young people with type 1 diabetes compared with healthy control subjects.
Subject: RISK-FACTORS
MICROBLEEDS
STROKE
RETINOPATHY
PREVALENCE
3121 General medicine, internal medicine and other clinical medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Cerebral_small_ ... al_draft_of_manuscript.pdf 186.0Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record