Clinical and MRI Features of Cerebral Small-Vessel Disease in Type 1 Diabetes

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Thorn , L M , Shams , S , Gordin , D , Liebkind , R , Forsblom , C , Summanen , P , Hägg-Holmberg , S , Tatlisumak , T , Salonen , O , Putaala , J , Martola , J & Groop , P-H 2019 , ' Clinical and MRI Features of Cerebral Small-Vessel Disease in Type 1 Diabetes ' , Diabetes Care , vol. 42 , no. 2 , pp. 327-330 . https://doi.org/10.2337/dc18-1302

Title: Clinical and MRI Features of Cerebral Small-Vessel Disease in Type 1 Diabetes
Author: Thorn, Lena M.; Shams, Sara; Gordin, Daniel; Liebkind, Ron; Forsblom, Carol; Summanen, Paula; Hägg-Holmberg, Stefanie; Tatlisumak, Turgut; Salonen, Oili; Putaala, Jukka; Martola, Juha; Groop, Per-Henrik
Contributor organization: Nefrologian yksikkö
Clinicum
University of Helsinki
Research Programs Unit
Diabetes and Obesity Research Program
HUS Abdominal Center
Department of Medicine
Faculty of Medicine
Neurologian yksikkö
HUS Neurocenter
HUS Head and Neck Center
Department of Ophthalmology and Otorhinolaryngology
Department of Neurosciences
Department of Diagnostics and Therapeutics
HUS Medical Imaging Center
Per Henrik Groop / Principal Investigator
Date: 2019-02-01
Language: eng
Number of pages: 4
Belongs to series: Diabetes Care
ISSN: 0149-5992
DOI: https://doi.org/10.2337/dc18-1302
URI: http://hdl.handle.net/10138/311320
Abstract: OBJECTIVETo assess the prevalence of cerebral small-vessel disease (SVD) in subjects with type 1 diabetes compared with healthy control subjects and to characterize the diabetes-related factors associated with SVD.RESEARCH DESIGN AND METHODSThis substudy was cross-sectional in design and included 191 participants with type 1 diabetes and median age 40.0 years (interquartile range 33.0-45.1) and 30 healthy age- and sex-matched control subjects. All participants underwent clinical investigation and brain MRIs, assessed for cerebral SVD.RESULTSCerebral SVD was more common in participants with type 1 diabetes than in healthy control subjects: any marker 35% vs. 10% (P = 0.005), cerebral microbleeds (CMBs) 24% vs. 3.3% (P = 0.008), white matter hyperintensities 17% vs. 6.7% (P = 0.182), and lacunes 2.1% vs. 0% (P = 1.000). Presence of CMBs was independently associated with systolic blood pressure (odds ratio 1.03 [95% CI 1.00-1.05], P = 0.035).CONCLUSIONSCerebral SVD, CMBs in particular, is more common in young people with type 1 diabetes compared with healthy control subjects.
Subject: RISK-FACTORS
MICROBLEEDS
STROKE
RETINOPATHY
PREVALENCE
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion


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