Sugar sensing by ChREBP/Mondo-Mlx - new insight into downstream regulatory networks and integration of nutrient-derived signals

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Havula , E & Hietakangas , V 2018 , ' Sugar sensing by ChREBP/Mondo-Mlx - new insight into downstream regulatory networks and integration of nutrient-derived signals ' , Current Opinion in Cell Biology , vol. 51 , pp. 89-96 . https://doi.org/10.1016/j.ceb.2017.12.007

Title: Sugar sensing by ChREBP/Mondo-Mlx - new insight into downstream regulatory networks and integration of nutrient-derived signals
Author: Havula, Essi; Hietakangas, Ville
Contributor organization: Centre of Excellence in Stem Cell Metabolism
Molecular and Integrative Biosciences Research Programme
Doctoral Programme in Integrative Life Science
Nutrient sensing laboratory
Institute of Biotechnology
Faculty of Biological and Environmental Sciences
Date: 2018-04
Language: eng
Number of pages: 8
Belongs to series: Current Opinion in Cell Biology
ISSN: 0955-0674
DOI: https://doi.org/10.1016/j.ceb.2017.12.007
URI: http://hdl.handle.net/10138/311367
Abstract: Animals regulate their physiology with respect to nutrient status, which requires nutrient sensing pathways. Simple carbohydrates, sugars, are sensed by the basic-helix-loop-helix leucine zipper transcription factors ChREBP/Mondo, together with their heterodimerization partner Mlx, which are well-established activators of sugar-induced lipogenesis. Loss of ChREBP/Mondo-Mlx in mouse and Drosophila leads to sugar intolerance, that is, inability to survive on sugar containing diet. Recent evidence has revealed that ChREBP/Mondo-Mlx responds to sugar and fatty acid-derived metabolites through several mechanisms and cross-connects with other nutrient sensing pathways. ChREBP/Mondo-Mlx controls several downstream transcription factors and hormones, which mediate not only readjustment of metabolic pathways, but also control feeding behavior, intestinal digestion, and circadian rhythm.
Subject: ELEMENT-BINDING PROTEIN
X-RECEPTOR LXR
CENTER-DOT-MLX
TRANSCRIPTION FACTOR
GENE-EXPRESSION
SUBCELLULAR-LOCALIZATION
DROSOPHILA-MELANOGASTER
METABOLITE REGULATION
GLUCOSE-METABOLISM
MOUSE-LIVER
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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