Sugar sensing by ChREBP/Mondo-Mlx - new insight into downstream regulatory networks and integration of nutrient-derived signals

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Havula , E & Hietakangas , V 2018 , ' Sugar sensing by ChREBP/Mondo-Mlx - new insight into downstream regulatory networks and integration of nutrient-derived signals ' , Current Opinion in Cell Biology , vol. 51 , pp. 89-96 . https://doi.org/10.1016/j.ceb.2017.12.007

Title: Sugar sensing by ChREBP/Mondo-Mlx - new insight into downstream regulatory networks and integration of nutrient-derived signals
Author: Havula, Essi; Hietakangas, Ville
Contributor: University of Helsinki, Centre of Excellence in Stem Cell Metabolism
Date: 2018-04
Language: eng
Number of pages: 8
Belongs to series: Current Opinion in Cell Biology
ISSN: 0955-0674
URI: http://hdl.handle.net/10138/311367
Abstract: Animals regulate their physiology with respect to nutrient status, which requires nutrient sensing pathways. Simple carbohydrates, sugars, are sensed by the basic-helix-loop-helix leucine zipper transcription factors ChREBP/Mondo, together with their heterodimerization partner Mlx, which are well-established activators of sugar-induced lipogenesis. Loss of ChREBP/Mondo-Mlx in mouse and Drosophila leads to sugar intolerance, that is, inability to survive on sugar containing diet. Recent evidence has revealed that ChREBP/Mondo-Mlx responds to sugar and fatty acid-derived metabolites through several mechanisms and cross-connects with other nutrient sensing pathways. ChREBP/Mondo-Mlx controls several downstream transcription factors and hormones, which mediate not only readjustment of metabolic pathways, but also control feeding behavior, intestinal digestion, and circadian rhythm.
Subject: ELEMENT-BINDING PROTEIN
X-RECEPTOR LXR
CENTER-DOT-MLX
TRANSCRIPTION FACTOR
GENE-EXPRESSION
SUBCELLULAR-LOCALIZATION
DROSOPHILA-MELANOGASTER
METABOLITE REGULATION
GLUCOSE-METABOLISM
MOUSE-LIVER
1182 Biochemistry, cell and molecular biology
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