American Society of Anesthesiologists physical status score as a predictor of long-term outcome in women with endometrial cancer

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http://hdl.handle.net/10138/311370

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Kolehmainen , A M , Pasanen , A , Tuomi , T , Koivisto-Korander , R , Butzow , R & Loukovaara , M 2019 , ' American Society of Anesthesiologists physical status score as a predictor of long-term outcome in women with endometrial cancer ' , International Journal of Gynecological Cancer , vol. 29 , no. 5 , pp. 879-885 . https://doi.org/10.1136/ijgc-2018-000118

Title: American Society of Anesthesiologists physical status score as a predictor of long-term outcome in women with endometrial cancer
Author: Kolehmainen, Anne Maarit; Pasanen, Annukka; Tuomi, Taru; Koivisto-Korander, Riitta; Butzow, Ralf; Loukovaara, Mikko
Contributor: University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, HUSLAB
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, HUS Gynecology and Obstetrics
University of Helsinki, HUSLAB
University of Helsinki, Department of Obstetrics and Gynecology
Date: 2019-06
Language: eng
Number of pages: 7
Belongs to series: International Journal of Gynecological Cancer
ISSN: 1048-891X
URI: http://hdl.handle.net/10138/311370
Abstract: Objective To study the association of the American Society of Anesthesiologists (ASA) physical status score with long-term outcome in endometrial cancer. Methods Overall, disease-specific and non-cancer-related survival were estimated using simple and multivariable Cox regression analyses and the Kaplan-Meier method. Results A total of 1166 patients were included in the study. Median follow-up time was 76 (range 1-136) months. All-cause and non-cancer-related mortality were increased in patients whose ASA physical status score was III (HRs 2.5 and 8.0, respectively) or IV (HRs 5.7 and 25, respectively), and cancer-related mortality was increased in patients whose score was IV (HR 2.7). Kaplan-Meier analyses demonstrated a worse overall, disease-specific and non-cancer-related survival for patients whose score was >= III (p= III in both subgroups of stages (p=0.003 and p=0.017 for stage I and stages II-IV, respectively). ASA physical status score remained an independent predictor of all-cause mortality (HR 2.2 for scores >= III), cancer-related mortality (HRs 1.7 and 2.2 for scores >= III and IV, respectively) and non-cancer related mortality (HR 3.1 for scores >= III) after adjustment for prognostically relevant clinicopathologic and blood-based covariates. ASA physical status score also remained an independent predictor of cancer-related mortality after exclusion of patients who were at risk for nodal involvement based on features of the primary tumor but who did not undergo lymphadenectomy, and patients with advanced disease who received suboptimal chemotherapy (HRs 1.6 and 2.5 for scores >= III and IV, respectively). Conclusions ASA physical status score independently predicts overall survival, disease-specific survival, and non-cancer-related survival in endometrial cancer.
Subject: PATTERNS
SURVIVAL
MORTALITY
ONCOLOGY
3123 Gynaecology and paediatrics
3122 Cancers
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