Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control

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Family Invest Nephropathy Diabet-E , DCCT EDIC Res Grp , Pollack , S , Groop , L , Toppila , I , Sandholm , N , Groop , P-H & Sobrin , L 2019 , ' Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control ' , Diabetes , vol. 68 , no. 2 , pp. 441-456 . https://doi.org/10.2337/db18-0567

Title: Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control
Author: Family Invest Nephropathy Diabet-E; DCCT EDIC Res Grp; Pollack, Samuela; Groop, Leif; Toppila, Iiro; Sandholm, Niina; Groop, Per-Henrik; Sobrin, Lucia
Contributor: University of Helsinki, Diabetes and Obesity Research Program
University of Helsinki, Clinicum
University of Helsinki, Research Programs Unit
Date: 2019-02-01
Language: eng
Number of pages: 16
Belongs to series: Diabetes
ISSN: 0012-1797
URI: http://hdl.handle.net/10138/311416
Abstract: To identify genetic variants associated with diabetic retinopathy (DR), we performed a large multiethnic genome-wide association study. Discovery included eight European cohorts (n = 3,246) and seven African American cohorts (n = 2,611). We meta-analyzed across cohorts using inverse-variance weighting, with and without liability threshold modeling of glycemic control and duration of diabetes. Variants with a P value
Subject: CHINESE PATIENTS
RISK-FACTORS
METAANALYSIS
LOCI
PREVALENCE
POLYMORPHISMS
VARIANTS
SEVERITY
RESOURCE
REVEALS
3121 General medicine, internal medicine and other clinical medicine
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